摘要
目的探讨猪后肢枪弹伤所致肺远达效应损伤的CT特征及发生机制。方法对14头猪随机采用高速弹射击,建立猪后肢枪弹伤轻等程度损伤(轻伤组,7头)和重伤动物(重伤组,7头)模型。分别在枪击前、后3、10、40min、6h,利用CT对动物模型的肺部组织结构进行观察,同时在枪击前、后3、10、25、40min、6h测定主要的血管活性物质[内皮素(ET)、皮质醇(COR)]及炎性反应指标[白细胞总数、白细胞介素-6(IL-6)]的变化。结果两组实验猪枪击后的肺部CT征象变化包括组织渗出、出血、细支气管炎、肺间质、实质渗出。肺损伤发展程度与枪弹伤伤情及ET、COR及IL-6的变化趋势相一致。IL-6在枪击后升高,ET、COR水平在枪击后各时间点均较枪击前上升。结论猪后肢枪弹伤所致肺远达效应是在致伤物动能、应激反应及神经体液因素等多种条件作用下的损伤,肺远达效应损伤伤情程度与枪弹伤伤情相一致。
Objective To explore the mechanism of lung far-reaching effect in gunshot on pig lower limbs.Methods Shots were made into the pigs＇ lower limbs to create minor wound（minor injury group,7 pigs） model and severe wound（serious injury group,7 pigs） model.CT manifestations of pulmonary structure pathological changes were assessed at the time of pre-gunshot,and 3,10,40 min,6 h after gunshot,meanwhile vasoactive substance（endothelin ,cortisol ） and inflammatory index（white blood cells,interleukin-6 ） were measured at the time of pre-gunshot,and 3,10,25,40 min,6 h after gunshot,respectively.Results Indirect lung injury caused by gunshot on lower limbs included tissues effusion,hemorrhage,bronchiolitis and pulmonary interstitial,substance effusion.The development of indirect lung injury showed a trend influenced by the injury severity and ET,COR and IL-6.The blood IL-6 level increased after gunshot.The levels of ET and COR at all time points after gunshot were higher than those pre-gunshot.Conclusion Lung far-reaching effect influenced by many factors,such as vulnerant kinetic energy,stress,inflammatory,neural humoral factors,and so on.The severity injury of far-reaching effect is consistent with the severity wound by gunshot.
出处
《中国介入影像与治疗学》
CSCD
2012年第5期385-388,共4页
Chinese Journal of Interventional Imaging and Therapy
基金
全军医药卫生科研基金课题(06MA207)
关键词
创伤
枪击
远达效应
体层摄影术
X线计算机
应激
炎症
Wounds
gunshot
Far-reaching effect
Tomography
X-ray computed
Stress
Inflammation
