摘要
本研究采用两种方法观察了消炎痛的肝保护作用与前列腺素的关系。1.用同样能抑制环氧化酶的阿斯匹林进行了类似的实验观察,结果在25～400mg/kg剂量范围内,用阿斯匹林预处理未观察到任何肝保护的现象,反而使肝损伤略有严重。2.消炎痛与二甲基前列腺素E_2合用,结果显示消炎痛的肝保护作用进一步增强。
The relationship between indomethacin induced hepatic protection and prostaglandin was observed. A similar experiment was done using aspirin-another inhibitor of PG synthesis instead of indomethacin, no protective effect was observed in a large range of dosage. Co-administration of dimPGE2 with indomethacin could potentiate the protective effect. These results suggest that the protective effect of indomethacin might be not related to its inhibition on PG synthesis. So, it is not contradictory that both indomethacin and prostaglandin induce hepatic protection. Their mechanisms perhaps are different. The potentiating effect of dimPGE2 on indomethacin for hepatic protection would be of important clinical value.
出处
《北京医科大学学报》
CSCD
1989年第5期365-367,共3页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
消炎痛
肝保护
前列腺素
四氯化碳
Indomethacin Carbon tetrachloride Prostaglandin Aspirin Hepatic prote-tion
