摘要
目的探讨HBV感染不同免疫状态(免疫耐受、免疫清除、免疫不全状态)者Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(C-Ⅳ)表达水平的差异及临床意义。方法将60例HBV感染后不同疾病阶段者分为免疫耐受状态(免疫耐受组)、免疫清除状态(免疫清除组)和免疫不全状态(免疫不全组)各20例;另选20例健康体检者作为对照组。收集研究对象静脉血,应用电化学发光法检测PCⅢ、C-Ⅳ表达水平。结果 PCⅢ水平:免疫清除组、免疫不全组高于对照组(z值分别为-5.041、-4.095,P均<0.05),免疫清除、免疫不全组与免疫耐受组比较差别有统计学意义(z值分别为-5.356、-4.599,P均<0.05)。C-Ⅳ水平:免疫清除组、免疫不全组与对照组比较差异有统计学意义(z值分别为-3.273、-4.166,P均<0.05),免疫清除、免疫不全组与免疫耐受组差别有统计学意义(z值分别为-2.570、-2.732,P均<0.05)。结论慢性HBV感染者血清PCⅢ、C-Ⅳ表达水平与机体的免疫调节状态密切相关,且对肝纤维化的诊断有重要的临床意义。
Objective To study the expression and significance of the serum levels of PC m and C-IV in patients with I-IBV infection during different immune status. Methods The patients of HBV infection were divided into three groups with immune tolerance, immune clearance, immunodeficiency. Serum samples were collected from 20 cases of immune tolerance, 20 cases of immune clearance, 20 cases of immunodeficiency and 20 cases of normal control. Serum levels of PC Ⅲ and C-Ⅳ were measured by the electrochemical luminescence method. Results The serum levels of PC Ⅲ in the immune clearance and immunodeficiency group were higher than those of the normal control group（z = -5. 041, -4. 095, all P 〈 0.05 ）. And the serum expression levels of PC Ⅲ of immune clearance group and immunodeficiency group were higher than those of immune tolerance group respectively （z = -5. 356, -4. 599, all P 〈 0.05 ）. The serum levels of C-IV in immune clearance group and immunodeficiency group had significant difference with normal control group respectively（z= -3. 273, -4. 166, all P 〈 0.05 ）. The serum expression levels of C-IV in immune clearance and immunodeficiency group were high er than those in immune tolerance group respectively （z = - 2. 570, - 2. 752, all P 〈 0.05 ）. Conclusion Serum levels of PCⅢ, C-Ⅳ are closely related with the immune status in patients with chronic HBV infection. The expression levels of PC Ill, C-IV have important clinical significance to the diagnosis of hepatic fibrosis.
出处
《山东医药》
CAS
2012年第13期10-12,共3页
Shandong Medical Journal
基金
国家自然科学基金资助项目(30760294)
广西科学研究与技术开发计划项目(桂科攻10124001B)
关键词
肝炎
乙型
慢性
免疫状态
前胶原
hepatitis B, chronic
immune status
procollagen
