摘要
目的:探讨RANTES及肥大细胞(MC)在口腔扁平苔藓(OLP)发生发展过程中的作用及意义。方法:采用SABC免疫组化法检测30例OLP黏膜组织及10例正常口腔黏膜组织中RANTES的表达及MC的数量,根据Bresalier半定量公式计算RANTES的平均染色强度。结果:RANTES的平均染色强度在正常对照组低于OLP非糜烂型组低于OLP糜烂型组,三组之间两两差异均有统计学意义(P<0.05)。MC密度正常对照组低于OLP非糜烂型组低于OLP糜烂型组,三组之间的两两差异均有统计学意义(P<0.05)。MC密度与RANTES表达呈正相关(r=0.850,P<0.01)。结论:MC及RANTES可能参与了OLP的致病机制,且两者间有相关性。
Objective：To explore the role of MC and RANTES in the process of OLP.Method：Immunohistochemistry of SABC were used to identify MC density and the expressions of RANTES in the study of oral mucosa with OLP（n=30） and normal oral mucosa（NOM）（n=10）.An average staining intensity score was determined by using ＂Bresalier＂ semiquantitative scoring system.Result：The average staining intensity of RANTES in the control group was lower than the OLP non-erosion group,and the difference between each other group carried statistical significance（P 0.05）.The MC intensity of control group was lower than the OLP non-erosion group,while the OLP erosion group maintained the lowest intensity.Difference between any two of the groups had statistical significance（P 0.05）,and a positive correlation existed between the intensity of MC and the expression of RANTES（r=0.850,P 0.01）.Conclusion：RANTES and MC might play a key role in the pathogenesis of OLP.and both of them were correlated.
出处
《临床口腔医学杂志》
2012年第5期277-279,共3页
Journal of Clinical Stomatology
关键词
口腔扁平苔藓
肥大细胞
T细胞表达
活性调节蛋白
oral lichen planus
mast cell
regulate upon activation normal T cell expressed and secreted
