摘要
目的探讨孕激素膜受体1(PGRMC1)在乳腺癌中的表达状况及与临床病理指标的可能关系。方法采用免疫组织化学方法回顾性分析检测60例乳腺癌PGRMC1的表达,并评价其与病理分级、临床分期、转移,化疗敏感性以及预后之间的关系。结果 60例乳腺癌组织PGRMC1表达阳性37例,阴性23例。PGRMC1的表达与乳腺癌淋巴结转移(P=0.004)、肿瘤大小(P=0.03)和临床分期(P=0.039)密切相关;与年龄(P=0.196)和肿瘤病理分级(P=0.526)无关。PGRMC1的表达与乳腺癌患者的总体生存率(Log-rank=15.638;P=0.0001)和无瘤生存率(Log-rank=4.443;P=0.035)有关。多因素分析结果提示PGRMC1是乳腺癌独立的预后因子(P=0.002)。结论 PGRMC1的表达乳腺癌随转移和临床分期升高而增强,可能是乳腺癌的预后因素之一。
Objective To investigate the correlation of the expression of progesterone receptor membrane component-1 to the clinicopathological features of breast cancer.Methods The expression of PGRMC1 was detected immunohistochemically in 60 surgical specimens of breast cancer,and the association of PGRMC1 with the histological grade,lymphatic metastasis,TNM stage and prognosis was assessed.Results Positive CA-9 expression was detected in 37（61.67%） of the cases.PGRMC1 expression was significantly correlated to lymph node metastasis（P=0.004）,tumor size（P=0.03）,TNM stage（P=0.039）,overall survival rate（Log-rank=10.378,P=0.0001）,and tumor-free survival（Log-rank=4.443,P=0.035）,but not to the patients＇ age（P=0.196） or histological grade（P=0.526）.Multivariate survival analysis indicated that PGRMC1 was an independent prognostic factor of breast cancer（P=0.002）.Conclusions The expression of PGRMC1 is strongly associated with the progression of breast cancer,and may serve as a useful prognostic indicator of the malignancy.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2012年第5期635-638,共4页
Journal of Southern Medical University
基金
国家自然科学基金(81072176)~~
关键词
乳腺癌
孕激素膜受体1
预后
breast cancer
progesterone receptor membrane component-1
prognosis
