摘要
目的探讨弥漫增生型狼疮性肾炎（ＤＰＬＮ）的病理参数即活动性指数（ＡＩ）及慢性指数（ＣＩ）与病程、临床分型、肾功能之间的关系，用于判断预后及指导治疗。方法对３０例ＤＰＬＮ患者肾穿刺活检组织形态学进行半定量分析，观察ＡＩ、ＣＩ与病程、临床分型及肾功能三者之间的关系。结果ＡＩ、ＣＩ与ＤＰＬＮ的临床分型、肾功能有明显相关，ＡＩ≥１０分，ＣＩ≥６分，提示预后不良，ＡＩ与病程无关，ＣＩ与病程有关联。结论ＡＩ、ＣＩ能较准确地反映ＤＰＬＮ的活动性及损害程度，是一项判断肾脏病变严重度及预后的客观指标。
Objcctive The active index(AI) and chronic index(CI) are two pathologic indexes of diffuse proliferative lupus nephritis(DPLN). The purpose of this study was to analyse the significance of there indexes in the course, clinical typing and renal function of DPLN, so ass to judge the prognosis and guide the treatment. methods We made semi-quantitative analysis with histomorphological examinations of renopuncture in thirty DPLN patients and observed the relation between Al, CI and the course, clinical typing, renal function of DPLN. Results Al and CI had distinct correlation with the course, clinical typing and renal function of DPLN. If Al was more than 10 grade or CI more than 6 grade, the prognosis was bad. Al did not have relation with the course of DPLN. However, CI might predict the prognosis of DPLN. Conclusion Al and CI can reflect the degree of activity and chronic lesions of DPLN respectively, and therefore are useful in directing treatment and prognosis.
出处
《上海第二医科大学学报》
CSCD
2000年第1期64-66,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
弥漫增生型
狼疮性肾炎
临床分型
病理
diffuse proliferative lupus nephritis
active index
chronic index
clinical typing
renal funtion
