摘要
MicroRNA(miRNA)是一类长度约22 nt的小分子非编码RNA,通过转录后调控机制影响基因表达。miRNA几乎参与了与肿瘤相关的所有过程,包括增殖、分化、凋亡、转移、血管生成、免疫应答等,并且功能研究表明其在肿瘤中起着致癌或者抑癌基因的作用,因此阐明其在肿瘤发生、发展中的作用具有重要的理论意义。实验证明miRNA可能成为影响肿瘤信号通路中关键因子的重要治疗靶点以及肿瘤标志物。现就miRNA的产生、作用机制、研究方法以及常见的几种致癌或者抑癌miRNA予以综述。
MicroRNA（miRNA）represent a class of naturally occurring small non-coding RNA molecules of about 22 nucleotide length that regulate gene expression at the post-transcriptional level.miRNA mediate processes in tumorigenesis,such as proliferation,differentiation,apoptosis,metastasis,angiogenesis,inflammation and so on.Functional research reveals that miRNA can act as tumor suppressors or oncogenes,so it is of great theoretical significance to elucidate underlying mechanism of miRNA in the processes of tumorigenesis and development.Experimental evidences indicate that miRNA may represent a powerful therapeutic strategy to interfere with key molecular pathways involved in cancer and novel biomarkers.Here is to make a review on the biogenesis,mechanism of target recognition and the methods currently available for studying the role of miRNA in cancer and provide insights about the progress of some well-known miRNAs that act as oncogenes or tumor suppressors.
出处
《医学综述》
2012年第8期1170-1173,共4页
Medical Recapitulate
基金
南京医科大学肿瘤中心招标课题(11ZLKF06)
