摘要
目的:通过对子痫前期患者血清中的可溶性血管内皮生长因子受体1(soluble fms-like tyrosine kinase-1,sFlt-1)的表达水平的测定,探讨它与子痫前期发病的关系及意义。方法:选取子痫前期患者40例,其中包括轻度子痫前期10例和重度子痫前期30例,同时选取同期正常孕妇40例,采用酶联免疫吸附试验(ELISA)夹心法检测三组孕妇血清中的sFlt-1的水平。结果:子痫前期组血清sFlt-1为939.27±109.48ng/L,正常妊娠组为279.24±147.39ng/L,两组比较差异有统计学意义(P<0.01)。重度子痫前期组血清中sFlt-1为941.76±159.01ng/L,轻度子痫前期组血清中sFlt-1为928.13±141.27ng/L,两组比较差异无统计学意义(P>0.05)。结论:母体血清sFlt-1水平在正常妊娠组和子痫前期组之间是有明显差异的,但是与子痫前期的严重程度没有直接关系。
Objective： To observe the level of serum soluble fms-like tyrosine kinase-1（sFlt-1） in patients with preeclampsia Methods： 40 patients with preeclampsia were collected.Among them,10 cases were mild preeclampsia and 30 cases were severe preeclampsia.40 healthy pregnant women were selected as control.The serum level of sFlt-1 in the three groups was measured by using enzyme-linked immunosorbent assay（ELISA）.Results： The serum level of sFlt-1 was 939.27±109.48ng/L in preeclampsia group and 279.24±147.39ng/L in normal group（P0.01）.The serum level of sFlt-1 was 941.76±159.01ng/L in severe preeclampsia group and 928.13±141.27ng/L in mild preeclampsia group.There was no statistical significant difference between the two groups of patients with preeclampsia（P0.05）.Conclusion： Serum sFlt-1 level was significantly increased in patients with preeclampsia.However it is not directly related to the severity of preeclampsia.
出处
《泸州医学院学报》
2012年第2期169-171,共3页
Journal of Luzhou Medical College
