摘要
目的 :对慢性阻塞性肺部疾病 (COPD)院内感染老年患者 qd iv gtt奈替米星 (NTM)的药物动力学及其在下呼吸道的分布进行研究 ,并观察临床疗效和不良反应。方法 :以尿素作为肺泡液稀释内标 ,用荧光偏振免疫法测定血清、支气管分泌液和肺泡液中 NTM浓度。结果 :NTM7m g/ kg qd iv gtt(30 min) ,血清 cmax(2 6 .71± 4.95 ) mg/ L,消除半衰期 3.96 h;肺泡液中cmax(7.76± 2 .13) mg/ L ,相当于血清 cmax的 2 9%。支气管分泌液药物浓度与血药浓度无相关性。 qd给药使肺泡中药物浓度超过常见肺炎致病菌的 MIC值。连续用药 7d,31例患者未见肝、肾、神经毒性。结论 :NTM qd iv gtt,由于给药间隔长 ,可适用于 COPD院内感染老年患者。
AIM:To study the pharmacokinetics and distribution in the lower respiratory tract of netilmicin for iv gtt once daily in 31 chronic obstructive pulmonary disease (COPD) old patients with infection in hospital,the clinical efficacy and adverse reaction were also observed. METHODS: Urea was chosen as diluted internal standard of pulmonary alveoli solution. The drug concentration in serum, bronchus sec retion and pulmonary alveoli solution were determined with fluorescence polarization immunoassay (FPIA). RESULTS: The pharmacokinetic parameters of netilmicin 7 mg/kg for iv gtt (30 min) once daily were: c max =(26 71±4 95) mg/L, T 1/2 =3 69 h, t max =2 5 h, peak concentration in pulmonary alveoli solution was (7 76±2 13) mg/L, which was equivalent to 29% of the peak serum concentration. There was no interrelation between the concentration in the bronchus secretion and serum. The concentration in the pulmonary alveoli of netilmicin for iv gtt once daily was higher than the MIC of the common pathogen of pneumonia. No toxicity of liver, kidney and nerve were observed after 7 d serial dosage. CONCLUSION: Netilmicin for iv gtt once daily is applicable to old patients because of the long interval.
出处
《中国临床药学杂志》
CAS
2000年第1期24-27,共4页
Chinese Journal of Clinical Pharmacy
关键词
阻塞性肺疾病
奈替米星
药物动力学
疗效
netilmicin
once daily
old patient
pharmacokinetics
concentration in pulmonary alveoli solution
efficacy
adverse reaction
