摘要
目的:探讨子宫动脉灌注新辅助化疗对局部晚期宫颈癌的治疗效果。方法:选择行新辅助化疗的Ⅰb2-Ⅱb期宫颈癌病人88例为新辅助化疗组,化疗后行宫颈癌根治术或根治性放疗,55例同期同条件直接行宫颈癌根治术的病人为对照组,分析化疗后的近期疗效,并比较两组的淋巴结转移率、宫旁浸润率、阴道切缘阳性率的差异。结果:Ⅰb2-Ⅱb期宫颈癌病人行新辅助化疗后总有效率为88.64%,其中Ⅰb2期有效率为93.75%,Ⅱa期有效率为85.18%,Ⅱb期有效率为76.92%,经统计学分析,差异无显著性;鳞癌有效率为89.87%;腺癌有效率为77.78%,经统计学分析,差异无显著性。78例新辅助化疗有效者行手术治疗,新辅助化疗组的淋巴结转移率为10.25%,宫旁浸润率为6.41%,均低于对照组,差异有显著性(P<0.05)。结论:子宫动脉灌注新辅助化疗用于局部晚期宫颈癌的治疗,近期疗效显著,可缩小局部肿瘤、降低淋巴结转移率、改善宫旁情况、提高手术切除率、为手术治疗创造机会。
Objective ：To investigate the effects of intra- uterine arterial neoadjuvant chemothera- py in locally advanced cervical cancer. Method：A total of 88 patients with stage I b2 - ]1 b of cervical cancinoma were treated with neoadjuvant chemotherapy. After the chemotherapy was completed, the pa- tients underwent radical surgery or radiation therapy. This group was considered as the neoadjuvant chemotherapy group. A group of 55 cases with the same diagnoses received radical surgery alone. This group was considered as the control group. The effect of chemotherapy was analyzed. The rate of lymph node metastasis, parametrial invasion, vaginal margin involvement was compared between the two groups. Results：The overall response rate in the neoadjuvant chemotherapy group is 88.64% ,in which the response rate in the stage I b2 is 93.75% ,the stage Ⅱ a is 85.18% ,the stage Ⅱ b is 76.92%,there was no statistical significant difference between every two groups. The response rate in the patients with squamous cell carcinoma is 89.87% ,endocervical is 77.78% ,there was no statistical significant difference between two groups. Seventy - eight patients underwent surgery after neoadjuvant chemother- apy. The lymph node involvement in neoadjuvant chemotherapy group is 10.25%, the parametrial inva- sion is 6.41%, less than the control group, there was statistical significant difference between two groups（P 〈 0.05 ）. Conclusion ： The short - term effect of intra - uterine arterial neoadjuvant chemo- therapy on locally advanced cervical carcinoma is good. It can decrease the tumor volume, reduce the rate of lymph node relapse, reduce the rate of parametrial invasion, increase the resection rate, and pro- vide more opportunity for operation.
出处
《内蒙古医学院学报》
2012年第2期128-132,共5页
Acta Academiae Medicinae Neimongol
关键词
宫颈癌
新辅助化疗
动脉灌注
cervical cancer
neoadjuvant chemotherapy
arterial perfusion
