摘要
目的探讨妊娠期肝内胆汁淤积症(ICP)患者血清总胆汁酸(TBA)和肝功能的改变特点,分析其临床意义。方法收集50例ICP患者和50名正常妊娠女子空腹血清,测定血清TBA含量,同时检测血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT),观察ICP患者血清TBA和肝功能异常与母儿并发症及妊娠结局的关系。结果 ICP组血清TBA(73.9±13.6)μmmol/L,显著高于对照组(7.8±2.1)μmol/L,(P<0.01);ICP组血清ALT和AST及GGT分别为(98.5±6.8)U/L和(84.2±5.6)U/L及(143.9±14.7)U/L,显著高于对照组(32.5±5.1)U/L和(25.3±5.2)U/L及(35.1±4.5)U/L,(P均<0.01)。ICP患者肝功能及血清TBA值异常,可使孕妇自觉症状加重,倒置胎儿宫内窘迫,胎儿宫内发育迟缓,早产,产时并发症等。结论血清TBA和肝功能是敏感的指标,反映了病情的严重性,对ICP的临床诊断,疗效判断及病情发展有重要参考价值,可进一步提高了我们对ICP的认识。
Objective To investigate the characteristics of the alteration of the serum total bile acids（TBA） and the liver function in patients with intrahepatic cholestasis of pregnancy （ICP） and to analyze its clinical significance. Methods The fasting serum TBA and the liver function （ALTAST、 GGT） levels were measured in 50 patients with ICP and 50 healthy women with pregnancy were collected and were measured in the same time as controls. The abnormal liver function and abnormal metabolism of TBA for ICP, the complications of mothers and fetus, and the pregnancy ending were observed and their relations were analyzed. Results The level of serum TBA in ICP group was（73.9±13.6） μmmol/L,which was higher than that（7.8±2.1） μmol/L in the control group（P〈0.01）.The levels of serum ALT, AST and GGT in ICP group were（98.5±6.8）U/L,（84.2±5.6）U/L and（143.9±14.7）U/L respectively,which were obviously higher than those（32.5±5.1）U/L,（25.3±5.2）U/L and（35.1±4.5）U/L in the control group（P〈0.01）.Conclusion For patients with ICP, serum TBA and liver function were sensitive index to reflect severe degree of the disease, and they possess important reference value in clinical diagnosis, verdict curative effect and clinical development of the diseases.
出处
《中国实用医药》
2012年第7期22-23,共2页
China Practical Medicine
关键词
妊娠
肝内胆汁淤积
肝功能
总胆汁酸
血清
Pregnancy
Intrahepatic cholestasis
Liver function
Total bile acids
Serum
