摘要
目的 探讨血清 HA、PC 对慢性肝炎、肝炎肝硬化的诊断价值 ,HA与 PC 间相关关系以及它们的变化对预后的影响。方法 采用 RIA法同时检测慢性肝炎、肝炎肝硬化患者血清 HA、PC 含量 ,比较 HA、PC 间关系 ,肝炎肝硬化组中存活病例与死亡病例的 HA、PC 变化情况。结果 慢性肝炎轻、中、重度以及肝炎肝硬化患者血清 HA含量分别为 15 4.3±83.5 ,370 .0± 176 .1,6 0 9.3± 2 84.9和 10 5 9.2± 416 .2 ng/ml;PC 含量分别为 135 .3± 5 6 .5 ,15 6 .5± 49.3,2 0 0 .8± 75 .9和188.7± 87.8ng/ml,HA与 PC 间相关系数为 0 .137。死亡病例、存活病例其 HA、PC 值分别是 16 2 1.6± 5 96 .0 ,975 .0±42 1.7和 2 85 .6± 85 .1,16 9.8± 44 .8ng/ml,两者比较有显著性差异 (P<0 .0 5 )。结论 各型慢性肝炎、肝炎肝硬化患者血清HA、PC 含量均显著高于正常对照组 ,其血清 HA与 PC 间无明显相关 ;血清 HA、PC 值愈高 ,患者预后愈差。
Objective To explore the diagnostic values of hyaluronic acid(HA)and Type Ⅲ procollagen(PCⅢ)in serum of patients with chronic hepatitis and hepatitis-cirrhosis.Methods Measure the concentration of HA and PCⅢ in serum of the patients by using RIA,then assess the relation between HA and PCⅢ,and compare the changes of the concentration of HA and PCⅢ in surviving patients and dead patients.Results In patients with chronic hepatitis including mild,moderate and severe cases and hepatitis0-cirrhosis,the concentrations of HA were 154.3±83.5,370.0±176.1,609.3±284.9 and 1059.2±416.2ng/ml respectively ,whereas the concentrations of PCⅢ in these patients were 135.3±56.5,156.5±49.3,200.8±75.9 and 188.7±87.8ng/ml.The correlation coefficient was 0.137.The HA and PCⅢ in dead patients and surviving patients were 1621.6±596.0, 975.0±421.7 and 285.6±85.1, 169.8±44.8ng/ml,respectively(P<0.05).Conclusion The concentrations of HA and PCⅢin patients with chronic hepatitis and hepatitis cirrhosis were significantly higher than those in normal controls (P<0,05).No significant correlation was observed between HA and PCⅢ.The higher the serum concentration of HA,PCⅢ increased,the poorer the prognosis of the cases would be.
出处
《四川医学》
CAS
2000年第4期291-292,共2页
Sichuan Medical Journal
关键词
透明质酸
Ⅲ型前胶原
慢性肝炎
肝硬化
诊断
Hyaluronic acid Type Ⅲprocollagen Chronic hepatitis Hepatitis cirrhosis Diagnosis
