摘要
目的:探讨头孢曲松钠联合免疫增强剂治疗早期梅毒血清固定患者的疗效。方法:将62例早期梅毒血清固定患者随机分成两组,治疗组31例,以头孢曲松钠2.0g静滴,同时联合胸腺五肽注射液1mg肌肉注射,1次/日×15天复治;对照组31例,以水剂青霉素钠400万U静滴,4小时1次×15天,继以苄星青霉素240万U肌肉注射,每周3次复治。复治后第3、6、12、24个月复查血清RPR滴度。结果:复治6个月后,治疗组痊愈20例,痊愈率64.52%,对照组痊愈15例,痊愈率48.39%,两组差异性无统计学意义(X2=1.64,P>0.05)。复治24个月后,治疗组痊愈27例,痊愈率87.10%;对照组痊愈22例,痊愈率70.97%,两组差异性无统计学意义(X2=2.43,P>0.05)。结论:头孢曲松钠联合免疫增强剂治疗早期梅毒血清固定患者,与传统治疗方案相比,无显著性优势,临床疗效值得进一步评价。
Objective:To evaluate the value of ceftriaxone and thymopentin in the treatment of serofast of patients with early syphilis.Methods:Sixty-two early syphilis patients with serofast were randomly divided into 2 groups.The experiment group(31 cases)received the treatment with intravenous drips of ceftriaxone,2.0g and intramuscular injection of thymopentin,1.0g daily for 15 days,while the control groups(31 cases)were treated with intravenous drips of the large dose of aqueous penicillin 2400 pan U·d-1(400 panU per q4h) for 15 days,then intramuscular injection with benzathine penicillin 240 panU,weekly for 3 times.After 3,6,12 and 24 months,RPR was retestment for all the patients.A negative RPR test was judged as cure.Results:At month 6 after treatment,20 cases in experiment group and 15 cases in control group were cured.The cure rates in the two groups were 64.52% and 48.39%(P>0.05).At month 24 after treatment,27 cases in experiment group and 22 cases in control group were cured.The cure rates in the two groups were 87.10% and 70.97%(P>0.05).Conclusion:Ceftriaxone and thymopentin was no better than aqueous penicillin in the treatment of serofast of patients with early syphilis.Clinical efficacy deserved further evaluation.
基金
阳江市科技计划项目(卫[2008]12)
