摘要
研究了外源性缓激肽与硝酸甘油对豚鼠心脏过敏反应的保护作用 .豚鼠致敏后 ,离体心脏抗原攻击能显著降低冠脉流量 ,左室内压和左室内压最大变化速率以及延缓房室传导 .缓激肽 ( 50和 50 0nmol·L-1)与硝酸甘油 ( 30 0 nmol·L-1)能显著增加冠脉流出液中降钙素基因相关肽 ( CGRP)的含量 ,同时减轻心脏过敏所致的心功能下降和房室传导阻滞。结果提示 :外源性缓激肽与硝酸甘油对心脏过敏反应有保护作用 ,其作用可能与促进 CGRP释放有关 .
In the present study, the protective effects of exogenous bradykinin and nitroglycerin on cardiac anaphylaxis were examined. Isolated heart from presensitized guinea pig in vivo was challenged by antigen and resulted in a marked decrease in coronary flow (CF), left ventricular pressure (LVP) and its maximal rate of rise and decline of ventricular pressure (±dp/dt max ), and prolongation of P R interval. Bradykinin (50 or 500 nmol·L -1 ) and nitroglycerin (300 nmol·L -1 ) markedly increased the content of calcitonin gene related peptide (CGRP) concomitant with a significant improvement of the cardiac dysfunction and alleviation of the extension of P R interval. These results suggest that exogenous bradykinin or nitroglycerin be beneficial for cardiac anaphylactic reaction, and the protective effects be related to stimulation of CGRP release.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2000年第2期91-95,共5页
Chinese Journal of Pharmacology and Toxicology
基金
国家教育部<跨世纪人才培养计划>基金&&
关键词
心脏过敏
缓激肽
硝酸甘油
CGRP
cardiac anaphylaxis
bradykinin
nitroglycerin
calcitonin gene related peptide
