摘要
目的分析安徽省21例克-雅氏病病例的特点,为防治提供科学依据。方法按照《全国克雅氏病监测方案》,对病例进行个案调查,调查发病经过、治疗情况,实验室检测,传播途径及暴露因素等。结果 21例克-雅氏病例初期临床表现主要为精神症状发作,易出现烦躁易怒、注意力不集中等类神经症状。散发病例占76.19%(16/21),遗传性占23.81%(5/21)。结论 5例病人的14-3-3蛋白阳性,5例病人的Prp基因有突变,具有家族遗传性;克-雅氏病的感染来源、治疗和影响因素等问题尚待进一步研究。
Objective To analyze characteristics of 21 cases of Creutzfeldt-Jakob disease（CJD）,and provide evidence for the prevention and treatment.Methods According to national surveillance scheme of CJD,case survey was conducted among all cases to investigate their process of the pathogenesis and treatment,laboratory tests,transmission routes and risk factors,etc.Results The main clinical symptoms of 21 cases were some psychotic symptoms during the early stage,and the cases also showed to be more prone to similar psychotic symptoms,such as dysphoria,irascibility and lacking of concentration.Among 21 cases,sporadic cases accounted for 76.19%（16/21）,genetic cases accounted for 23.81%（5/21）.Conclusion There were 5 cases with 14-3-3 protein positive,and 5 ones with Prp gene mutation and familial transmissibility.Further research is needed on source of infection,treatment and impact factors of CJD.
出处
《安徽预防医学杂志》
2012年第2期82-83,86,共3页
Anhui Journal of Preventive Medicine
关键词
克-雅氏病
病例分析
Creutzfeldt-Jakob Disease
Case
Analysis
