摘要
目的 :为研究食管癌病人癌组织中 myc基因的扩增情况 ,探讨 myc基因与食管癌浸润和转移的关系。方法 :采用聚合酶链反应 (PCR)进行测定。结果 :淋巴结转移阳性组的 myc基因扩增率 (71.4% )明显高于淋巴结转移阴性组 (16 .7% ) ,且myc族癌基因的扩增率随癌浸润程度的加重而增高 ,具有明显相关性 (P<0 .0 5 )。结论 :myc族癌基因的过表达与食管癌的浸润和转移关系密切 ,m yc基因的表达情况可作为评价食管癌预后新的指标。
Objective To study the relationship between myc oncogene and metastasis and invasion of esophygeal carcinoma.Methods using ploymerase chain reaction,20 patients with esophygeal carcinoma were studied.Results In this research the amplification rate of lymphnodes-metastasis group(71 4%)was significantly higher than that of nonlymphnodes-metastasis group(16 7%).Furthermore,the amplification rate of myc increased gradually along with the severity of invasion and statistically significant correlation exists between them(P<0 05).Conclusion myc gene had close relationship with metastasis and invasion of esophygeal carcinoma the expression of myc oncogene may be a new indicator to assess the prognosis of esophygeal carcinoma.
出处
《吉林医学》
CAS
2000年第2期75-76,共2页
Jilin Medical Journal
关键词
myc族癌基因
食管癌
浸润
转移
myc oncogene Esophygeal carcinoma Metastasis and invasion
