摘要
目的 探讨核仁组成区嗜银颗粒的计数对于区别乳腺及甲状腺良恶性病变的诊断价值。方法 采用针吸细胞技术对乳腺及甲状腺病变穿刺标本进行核仁组成区嗜银颗粒定量分析研究。结果 4 3例不同类型乳腺癌 ,嗜银颗粒平均值 4 .4 0 (P <0 .0 1) ,12例乳腺上皮良性增生 ,平均值 2 .90 ,4 5例不同类型甲状腺癌 ,嗜银颗粒平均值 3.50 (P <0 .0 1) ,10例甲状腺上皮良性增生 ,平均值 1.77,良、恶性肿瘤细嗜银颗粒的体积和形态有明显差别。结论 核仁组成区嗜银颗粒的计数对于区别乳腺和甲状腺良、恶性病变具有一定诊断价值 ,同时对平均值 ,大中颗粒百分比和异形颗粒百分比等三项参数进行综合分析 ,将会大大提高其诊断和鉴别诊断价值。
Objective To investigate the diagnostic value of AgNOR counts in benign and malignant lesions of breast and thyroid.Methods The quantitative analysis of AgNOR for aspirating samples of breast and thyroid neoplasms were detcted by fine-needle aspiration smears.Results Average value of AgNOR were 4.40(P<0.01) in 43 breast carcinomas,3.50 in 45 thyroid carcinomas,and bycontrast,2.90 in 12 epithelium benign hyperplasia of breast,1.77 in 10 epithelium benign hyperplasia of thyroid.The volume and figure of AgNOR granules were quite different in benign and malignant tumor cells.Conclusions The count of AgNOR may be of value in differential diagnosis of benign and malignant tumors of breast and thyroid.The complex analysis of average value and percentage of large,middle and heterogeneous granules will be significent for differential diagnosis of breast and thyroid neoplasms.
出处
《济宁医学院学报》
2000年第1期6-8,共3页
Journal of Jining Medical University
基金
山东省自然科学基金资助课题!(94C1026)
