摘要
目的调查安徽省胺碘酮致药品不良反应(ADR)情况并分析相关因素。方法检索安徽省2005年1月1日～2010年11月31日呈报的与胺碘酮相关的ADR报告表,筛选合格报告表120例,进行统计分析。结果 ADR多发生在40～80岁,男性多于女性;以一般不良反应居多。主要由口服途径给药引起,多发生于给药后1～7 d内;可累及多个系统/器官,多为恶心、呕吐或便秘;多数较轻微,停药或/和对症处理后可好转、治愈。结论医务人员应重视胺碘酮所致ADR,并进一步加强ADR监测。
Objective To study the condition and analyze the related factors of amiodarone-induced adverse drug reactions（ADR） in Anhui province.Methods Amiodarone-related ADR reports reported in Anhui province from Jan 1,2005 to Nov 31,2010 were searched,from which a total of 120 qualified amiodarone-induced ADR reports were screened out and analyzed statistically.Results Amiodarone-induced ADR occured more in males,aged from 40 to 80,most of which were not serious.They were majorly induced by oral administration,and majorly occured within 1 to 7 days.They might involve multi-organs or systems,and their clinical manifestations were chiefly nausea,vomiting or constipation.Most were relatively mild,and subsided after amiodarone withdrawal.Conclusion Medical staffs should pay much attention to amiodarone-induced ADR,and ADR monitoring should be more strengthened.
出处
《安徽医药》
CAS
2012年第4期550-552,共3页
Anhui Medical and Pharmaceutical Journal
