波立维联合拜阿司匹林治疗不稳定型心绞痛临床研究被引量：2

Clinical research on clopidogrel combined with aspirin in unstable angina pectoris treatment

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摘要目的探讨波立维联合拜阿司匹林治疗不稳定型心绞痛（UPA）的疗效和安全性。方法将UPA患者随机分为治疗组75例和对照组73例，治疗组用波立维75mg，1日1次，共7天，拜阿司匹林100mg，1日1次，共7天；对照组用安慰剂，1日1次，连续7天，拜阿司匹林100mg，1日1次，共7天。结果治疗组总有效率为94．7％，对照组为79．4％，两组疗效差异有显著性（P〈0．05）。结论治疗组较对照组起效快，作用强，效果好，安全性高。 Objective To investigate the efficacy and safety of using Clopidogrel combined with aspirin in treatment for unstable angina pectoris （UAP）. Methods The UAP patients were randomly divided into two groups： the treatment group （ n = 75 ） and the control group （ n = 73）. The patients in the treatment group took 75 mg Clopidogrel and 100 nag aspirin once a day for a week. The patients in the control group took Placebot once a day for a week.Results Curative effects of the treatment group was obviously better than that of the control group with the cure rate 94.7% vs 79,4%, which was really statistically meaningful （P〈 0.05）. Conclusion The treatment in the first group has a quicker, stronger and better effect and is reliably safe.

作者冼飞宁观林

机构地区吴川市人民医院

出处《国际医药卫生导报》 2012年第8期1145-1146,共2页 International Medicine and Health Guidance News

关键词波立维联合拜阿司匹林不稳定型心绞痛疗效 Clopidogrel combined with Aspirin unstable angina pectoris （UAP） Curative effect

分类号 R541.4 [医药卫生—心血管疾病]

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1Braunwald E, Antman EM, Beasley JW, et al.ACC/ AHA 2002 guideline update for the management of pa- tients with unstable angina andnon-ST-segment eleva- tion m~oca~dia~ infarction-summa~ ar~ic~ a report of the American College of Cardiology/American Heart As- sociation task force on practice guidelines (Committee on the Management of Patients With Unstable Angina)[J].J Am Coll Cardiol, 2002, 40(7)~ 1366-1374.
2邢晓春.氯吡格雷治疗不稳定型心绞痛疗效观察.中华中西医杂志,2005,6(17):1661-1663.
3EricJ.Topol.RobertM.Califf,EricN.Prystowsky,等.Topoi心血管病学[M].胡大一,译.北京:人民卫生出版社,2009:276.
4王吉耀.内科学上册[M].北京:人民卫生出版社,2008:257-298.
5张辉,赵旭兰,王凤飞,郑红梅.氯吡格雷、低分子肝素与阿司匹林联用治疗不稳定型心绞痛临床观察[J].临床荟萃,2004,19(11):609-611. 被引量：45

二级参考文献7

1ARBUSTINI E, de SERVI S, BRAMUCCI E, et al. Comparison of coronary lesions obtained by directional coronary atherectomy in unstable angina, stable angina, and restenosis after either atherectomy or angioplasty[J].Am J Cardiol,1997,75(10):675-682.
2THEROXS P, WATERS D, QIU S, et al. Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina[J]. Circulation,1998,88(5 Pt 1):2045-2048.
3CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events [J]. Lancet,1996,348(9038):1329-1339.
4YUSUF S, MEHTA S R, ZHAO F, et al. Early and late effects of clopidogrel in patients with acute coronary syndromes[J]. Circulation, 2003,107(7):966-972.
5GERSCHUTZ G P, BHATT D L. The Clopidogrel in Unstable Angina to Prevent Recurrent Events study: to what extent should the results be generalizable? [J].Am Heart J,2003,145(4):595-601.
6第一届全国内科学术会议心血管组.中华心血管病杂志,1981,9(1):75-7.
7刘国仗,胡大一,陶萍,诸骏仁,郭林妮,郭静萱,游凯.心血管药物临床试验评价方法的建议[J].中华心血管病杂志,1998,26(1):5-11. 被引量：1439