摘要
目的 :观察高甘油三酯 (TG)合并低高密度脂蛋白胆固醇 (HDL- C)患者在服用吉非罗齐治疗的同时对胰岛素敏感性的影响。方法 :测定 46例高 TG合并低 HDL- C血症而不伴有高血压及冠心病的患者应用吉非罗齐治疗 12周前后及 40例健康人 (正常对照组 )血 TG、HDL- C、血糖 (SG)及胰岛素 (INS)变化 ,并计算胰岛素敏感性指数 (ISI)。结果 :吉非罗齐治疗前 ,治疗组 INS显著升高 (P <0 .0 1) ,ISI明显降低 (P <0 .0 1) ,两组 SG无明显差异 (P >0 .0 5 )。吉非罗齐治疗 12周后 ,治疗组 INS明显下降 (P <0 .0 5 ) ,ISI显著增高 (P <0 .0 5 ) ,TG明显降低 (P <0 .0 1) ,HDL - C明显增高 (P <0 .0 5 )。结论 :高 TG合并低 HDL - C血症患者存在胰岛素抵抗 (ISR) ,吉非罗齐治疗后 ,在改善血脂代谢的同时 ,也改善机体
Objective:[WT9.,8.5BZ]To investigate the effects of gemifibrozil on insulin sensitivity in patients with hypertriglyceridemia and low high density lipoprotein(HDL C).[WT9.,8.5HZ]Method:[WT9.,8.5BZ]Fasting serum glucose (SG),insulin (INS),triglyceride(TG) and HDL C were measured and insulin sensitivity index (ISI) was calculated in 40 healthy subjects and 46 non hypertension,non coronary artery disease patients with hypertriglyceridemia and low HDL C before and after 12 weeks of gemifibrozil treatment.[WT9.,8.5HZ]Result:[WT9.,8.5BZ]Before treatment,INS in the patients group increased significantly (P< 0.01 ),and ISI significantly decreased (P< 0.01 ).There was′nt difference of SG between the patient and control group (P> 0.05 ).12 weeks after treatment,INS in the patient group significantly decreased (P< 0.05 ),and ISI significantly increased (P< 0.05 ),and TG significantly decreased (P< 0.01 ),and HDL C increased significantly (P< 0.05 ).[WT9.,8.5HZ]Conclusion:[WT9.,8.5BZ]Insulin resistance is occured in the patient with hypertriglyceridemia and low HDL C.Gemifibrozil has beneficial effects on lowering serum lipids and improving ISR. [WT9.,8.5HZ]
出处
《临床心血管病杂志》
CSCD
北大核心
2000年第2期76-77,共2页
Journal of Clinical Cardiology
关键词
吉非罗齐
甘油三酯
胰岛素抵抗
HDL-C
Gemifibrozil Triglyceridemia Lipoproteins
HDL Cholesterol Insulin resistance
