摘要
目的研究卵巢黏液性肿瘤中EGFR蛋白及CD44V6的表达及临床意义。方法应用免疫组化PV9000两步法分别检测20例卵巢黏液性囊腺瘤、40例卵巢黏液性交界性囊腺瘤和40例卵巢黏液性囊腺癌中EGFR蛋白和CD44V6的表达,同时分析其与临床病理特征和预后的关系。结果 EGFR在卵巢黏液性囊腺瘤、黏液性交界性囊腺瘤和囊腺癌中的阳性表达率分别为0.0%、37.5%、67.5%,囊腺癌组与其他2组相比差异有统计学意义(P<0.05);CD44V6在卵巢黏液性囊腺瘤、黏液性交界性囊腺瘤和囊腺癌中的阳性表达率分别为0.0%、7.5%、65.0%。EGFR与卵巢黏液性囊腺癌的临床分期、病理分级、患者年龄无关(P>0.05),与肿瘤的大小相关(P<0.05)。EGFR与卵巢黏液性交界性肿瘤临床病理分期、肿瘤大小、患者年龄无关(P>0.05)。CD44V6与卵巢黏液性囊腺癌临床病理分期、组织学分级、肿瘤大小、淋巴结转移相关(P<0.05)。EGFR和CD44V6的表达在卵巢黏液性囊腺癌的表达呈正相关(r=0.58,P<0.05)。结论 EGFR对卵巢黏液性交界性囊腺瘤和卵巢黏液性囊腺癌的形成起到了一定的作用,CD44V6高表达可能是卵巢黏液性囊腺癌预后判断的独立危险因素。
Objective To investigate the expression of epidermal growth factor receptor （EG- FR） and CD44V6 in ovarian mucinous tumors and the clinical significance. Methods The expres- sion of EGFR and CD44V6 was detected by immunohistochemical PV-9000 2-step method in 20 cases of ovarian cystadenoma, 40 cases of ovarian borderline mucinous cystadenoma and 40 cases of ovarian mucinous cystadenocarcinom. The relationship between clinicopathologic characteristics and prognostic significance was analyzed at the same time. Results The positive rates of EGFR expression were 0.0% ,37.5% and 67.5% and positive rates of CD44V6 expression were 0.0%, 7.5 % and 65.0% in ovarian cystadenoma, ovarian borderline mucinous cystadenoma and ovarian mucinous cystadenocarcinoma, respectively. The expression of EGFR was correlated with tumor size （P〈0.05） but not with clinical stage,histological grade and patient age in ovarian mucinous cystadenocarcinoma（P〉0.05）, and not with clinical stage, tumor size and patient age in ovarian borderline mucinous cystadenoma（P〉0.05）. The expression of CD44V6 was correlated with clinical stage,histological grade,tumor size and lymph node metastasis in ovarian mucinous cystade- nocarcinoma（P 〈 0.05）. Additionally, EGFR expression was positively correlated with CD44V6 expression ovarian mucinous cystadenocarcinoma （r= 0.58, P〈0.05）. Conclusion The EGFR plays a role in neoplasia of ovarian borderline mucinous cystadenoma and cystadenocarcinoma. High expression of CD44V6 may be an independent risk factor for prognosis of ovarian mucinous cystadenocarcinoma.
出处
《南昌大学学报（医学版）》
CAS
2012年第1期25-28,40,F0003,共6页
Journal of Nanchang University：Medical Sciences
基金
江西省卫生厅科技计划(2009-1232)
