摘要
目的:研究颈动脉斑块的影响因素及药物治疗的效果。方法:运用彩色多普勒超声检测颈动脉斑块及血管中内膜厚度,并检测血脂、血小板、C-反应蛋白等指标的变化,观察经阿托伐他汀治疗后各指标的变化。结果:经阿托伐他汀治疗后,颈动脉斑块有所缩小,且中内膜厚度变薄,差别有显著意义(P<0.05),CRP、低密度脂蛋白、高密度脂蛋白、血小板治疗前后及与对照组比较,差别均有显著意义(P<0.01)。结论:颈动脉斑块与C-反应蛋白、低密度脂蛋白、高密度脂蛋白及血小板的水平相关;阿托伐他汀治疗能稳定、逆转斑块。
Objective：To examine the factors involved in carotid plague formation and its sizes and the outcomes of medication.Methods：We performed color Doppler ultrasonography in all patients for detecting carotid plague condition and common carotid artery intima-media thickness（IMT） and examined the blood fat,platelets and c-reactive protein（CRP） for changes of these levels after medication of atorvastatin.Results：After atorvastatin therapy,the carotid plague was reduced and IMT became thinner（P0.05）.The levels of CRP,low density lipoprotein（LDL）,high density lipoprotein（HDL） and platelets were significantly different from pre-and post-medication as compared with the controls（P0.01）.Conclusion：Carotid plague formation and its diameter appears associated with levels of CRP,LDL,HDL and platelets.Atorvastatin can effectively manage the plague and even produce reverse effects.
出处
《皖南医学院学报》
CAS
2012年第2期116-119,共4页
Journal of Wannan Medical College
基金
芜湖市科技局科技计划项目(芜科计字[2007]126号)
关键词
颈动脉斑块
彩色多普勒超声
中内膜厚度
C-反应蛋白
低密度脂蛋白
高密度脂蛋白
阿托伐他汀
carotid plague
color Doppler ultrasound
intima-media thickness（IMT）
c-reactive protein
low density lipoprotein
high density lipoprotein
atorvasstatin
