摘要
目的:应用磁共振多回波T2*扫描定量计算肝硬化患者肝脏R2*值,并与血清铁蛋白含量进行相关性分析。材料和方法:对32例健康人和42例临床诊断为乙型肝炎后肝硬化和酒精性肝硬化患者行磁共振多回波T2*序列扫描,并采集静脉血样本测量血清铁蛋白浓度。应用SPIN软件分别测量健康人和肝硬化患者肝脏右叶前段和右叶后段R2*值,取其平均值与血清铁蛋白浓度进行Pearson相关性分析。结果:32例健康人和42例肝硬化患者肝脏R2*值分别为(67.02±12.32)Hz和(85.30±28.48)Hz,经两独立样本t检验,显示二者有显著差异,t=3.335,P=0.001。42例肝硬化患者血清铁蛋白浓度为(165.5±104.4)ng/mL(均值±标准差),R2*值与血清铁蛋白浓度的相关性分别为r=0.710,P=0.000。结论:肝硬化患者肝脏R2*值明显高于健康人,证明肝硬化患者肝脏铁浓度明显高于健康人。肝硬化患者肝脏R2*值与血清铁蛋白浓度有很好的相关性,证明R2*可以用于无创活体定量测量乙型肝炎后肝硬化和酒精性肝硬化患者肝脏内铁浓度。
Objective： Quantitative measurement of R2＊ in cirrhotic liver with MR multi-echo T2＊ sequence,and analyze its relationship with concentration of serum ferritin.Materials and Methods： Thirty-two healthy individuals and 42 patients with hepatic cirrhosis after chronic type B hepatitis and alcoholic cirrhosis had MR multi-echo T2＊ examination.The blood sample of patients was collected to assay concentration of serum ferritin.The SPIN software was used to measure the T2＊ value in health participants and cirrhotic patients.R2＊ value,which was the reciprocal of T2＊ value,was used to perform Pearson correlation analysis with serum ferritin concentration.Results： R2＊ value of healthy individuals and liver cirrhotic patients was（67.02±12.32） Hz,and（85.30±28.48） Hz,respectively.Independent sample t test showed significant difference between the two groups.The serum ferritin concentration of liver cirrhotic patients was（165.5±104.4） ng/mL.R2＊ value had significant correlation with serum ferritin concentrations in 42 patients（r=0.710,P=0.000）.Conclusion： R2＊ value was higher significantly in liver cirrhotic patients than that in healthy individuals,and had significant correlation with serum ferritin concentrations.It could be used for non-invasive quantitative measurement of the iron deposition in hepatic cirrhosis in vivo.
出处
《中国临床医学影像杂志》
CAS
2012年第4期253-255,共3页
Journal of China Clinic Medical Imaging
关键词
肝硬化
血清
铁蛋白
磁共振成像
Liver cirrhosis
Serum
Ferritin
Magnetic resonance imaging
