摘要
目的 :探讨阴茎癌淋巴结肿大与 ras癌基因 P 2 1蛋白的相关性。方法 :采用免疫组化 ABC法检测 110枚腹股沟淋巴结中 ras癌基因产物 P 2 1蛋白的表达状况 ,其中病理检查证实癌性和炎性肿大淋巴结各 40枚 ,正常淋巴结 80枚。结果 :P2 1蛋白在癌性、炎性和正常淋巴结中的阳性率分别为 92 .5 %、2 2 .5 %和 0 ;在炎性淋巴结中 ,P2 1蛋白阳性者平均 6个月和 17个月出现局部复发和骨盆转移。结论 :检测 P2 1蛋白表达状况 ,可提高癌前状态或癌前病变的诊断水平。
Purpose:To investigate the expression of Ras p21 protein in inguinal lymph nodes metastasis of human penis tumor and its clinical significance. Methods: Expression of ras oncogene product p21 protein in 110 specimens of inguinal lymph nodes were determined by immunohistochemical technique (ABC method). Results: Among these lymph nodes there were 40 of metastasis of cancer, 40 of inflammation and 30 of normal nodes. The positive rate of p21 protein was 92.5 %, 22.5 % and 0% respectively in these three groups. The patients of penis cancer with inflammation lymph nodes in which p21 protein was detected positive had poor prognosis. These patients would have local recurrence within half a year after operation and pelvic metastasis within 17 months on average.Conclusions:The determination of P21 protein may be helpful in the diagnosis of premalignant situation.
出处
《临床泌尿外科杂志》
2000年第2期66-67,共2页
Journal of Clinical Urology
