摘要
目的 探讨不同肠化亚型与胃癌发生的关系。方法 采用ABC免疫组化的方法 ,观察不同亚型肠化中PHA和CEA的变化。结果 (1)不全结肠型肠化PHA阳性表达率89 .3 % (P <0 .0 1) ,显著高于其它三型肠化。 (2 )不全结肠型肠化CEA阳性检出率 85 .7% ,P <0 .0 5 ,亦显著高于其它三型。 (3 )癌旁肠化中不全结肠型肠化占 5 9% ,显著高于良性病变伴肠化 (2 1.7% ,P <0 .0 5 )。结论 不全结肠型肠化与胃癌的关系密切 ,尤其是伴PHA和CEA过表达的不全结肠型肠化 ,应视为真正的胃癌前病变。
Objective To obeserve the relationship between the subtypes of intestinal metaplasia and gastric carcinoma.Methods Immunohistochemical studies with PHA and CEA were performed on tissues of intestinal metaplasia.Results 1.The rate of PHA receptors expression in incomplete colonic type intestinal metaplasia(ICIM)(89.3%,P<0.01)was significantly higher than other three subtypes;2.The positive rate of CEA in ICIM(85.7%,P<0.05)was also significantly higher than other three subtypes;3.The rate of ICIM in gastric carcinoma (59.0%)was higher than non-neoplastic disease (21.7%,P<0.05).Conclusion The ICIM is closely related to gastric careinoma,especially with overexpression of PHA and CEA,which should be considered as a real gastric precancerous lesion.
出处
《江西医药》
CAS
2000年第1期1-2,22,共3页
Jiangxi Medical Journal
基金
江西省自然科学基金
关键词
胃肿瘤
亚型
肠化生
PHA
CEA
Intestinal metaplasia phytohemagglutinins cancer embryonal antigen stomach neoplasms/etilogy
