摘要
目的探讨高血压患者记忆功能的现状及血压水平对记忆功能的影响，为临床干预措施提供依据。方法收集唐山市工人医院高血压患者196例为观察组，应用英国Rivermead康复中心设计的行为记忆测验第二版（RBMTII）对患者进行记忆功能测评。应用x。检验及多因素logistic回归分析检验影响高血压患者记忆功能的危险因素。结果不同分级的高血压患者的记忆障碍的患病率及程度随着血压水平的升高而加重（X2=10．389，P〈0．01）。高血压3级患者的RBMTII初评分与高血压1、2级患者比较，在回忆姓名、回忆被藏物品、脸部再认、路线延迟回忆、定向5项初评分及总标准分比较差异均有统计学意义（P〈0．05）。高血压2级患者与高血压1级比较回忆姓名、脸部再认及总标准总分比较差异亦有统计学意义（P〈0．05）。高血压3级患者与高血压1级比较回忆姓名、回忆被藏物品、脸部再认、定向及总标准总分比较差异有统计学意义（P〈0．05）；高血压3级与2级之间差异无统计学意义。高血压患者的年龄、性别、高血压病程、收缩压水平、体质指数是记忆功能障碍程度加重的危险因素，受教育年限是记忆功能障碍程度加重的保护因素。随着收缩压及脉压每升高20mmHg（1mmHg=0．155kPa），其患记忆功能障碍的危险有增长趋势（收缩压：OR=1．751，95％CI=1．355～2．263；脉压：OR=1．783，95％C1=1．381～2．301）。结论高血压患者的收缩压及脉压水平是高血压患者记忆功能障碍的最重要预测因素。高血压患者的记忆功能障碍以长时记忆损害为主，应加强血压水平的调节与控制，以维持和提高高血压患者的记忆功能。
Objective It is known that hypertension may be implicated the development of memory dysfunctin. Our study tests the hypothesis that prevalence of memory dysfunction is closely linked with the level of SBP （systolic blood pressure ） and DBP （diastolic blood pressure ） in hypertension patients. Methods Non-stroke hypertension patients aged 18 - 75 years （ n = 196, age 54 -＋ 10, 101 male） with diagnosed hypertension for more than one year were included. Memory function was measured by the Rivermead Behavioral Memory Test Second Edition （RBMT ]I , 2003 ）. The general information was obtained through questionnaire. Results RBMT 1I total score, the ability of recall name, remember storing article, recall faces, delayed route memory and orientation score were significantly decreased in proportion with increasing blood pressure （P 〈 0. 05 ： hypertension m vs. 11 and I ）. RBMT I1 total score, the ability of recall name, and recall faces were significantly lower in hypertension U group compared to hypertension I group （ P 〈 O. 05 ）. The age, male gender, years of hypertension, level of SBP and BMI were risk factors of memory dysfunction while the years of education was protective factor of memory dysfunction. The morbidity of memory dysfunction in patients with hypertension was higher and more serious with increasing blood pressure level（ X2 = 10. 389 ,P 〈0. 01 ）. Conclusions Our results suggest that blood pressure is positively related to increased risk of memory dysfunction. The age, male gender, years of hypertension, level of SBP and BMI are risk factors of memory dysfunction while the years of education is protective factor of memory dysfunction.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2012年第4期313-317,共5页
Chinese Journal of Cardiology
基金
河北省科技厅科技支撑项目（2009276103D-7）
关键词
高血压
血压
记忆障碍
Hypertension
Blood
Memory disorders
