摘要
目的探讨急性冠状动脉综合征患者置入药物洗脱支架后生命质量的变化，及其影响因素。方法连续入选2008年9月至2009年12月置入药物洗脱支架，并完成6个月临床随访的急性冠状动脉综合征患者共293例。分别于术前和术后6个月向患者发放SF-36生命质量调查表，并分析患者支架术后生命质量改善情况及其影响因素。结果与支架术前比较，术后6个月患者SF-36生命质量调查表的躯体健康总评和精神健康总评分值均有不同程度的升高[分别为（51．07±20．39）分比（61．69±19．73）分和（63．27±20．00）分比（68．81±18．71）分，P均〈0．01]。多元线性回归分析显示：女性、糖尿病以及ST段抬高型心肌梗死是躯体健康总评改善程度的独立影响因素（B值分别为-0．310、-3．880和1．302，P〈0．05或P〈0．01）；既往经皮冠状动脉介入治疗以及糖尿病是精神健康总评改善程度的独立影响因素（B值分别为-1．483和-2．790，P均〈0．01）。结论急性冠状动脉综合征患者置入药物洗脱支架后6个月，生命质量明显改善。女性、糖尿病以及ST段抬高型心肌梗死是躯体健康总评改善程度的独立影响因素，既往经皮冠状动脉介入治疗和糖尿病是精神健康总评改善程度的独立影响因素。
Objective To prospectively evaluate the change of quality of life in patients with acute coronary syndrome following percutaneous coronary intervention （PCI） with durg-eluting stents and explore the influencing factors of quality of life. Methods There hundred and thirty four consecutive patients with acute coronary syndrome receiving drug-eluting stents implantation between September 2008 and December 2009 were ettrolle＆ Of them, two hundred and ninety three patients completed 36-item short form health survey at baseline and 6 months after PCI procedure. Change of quality of life and influencing factors on quality of life were analyzed. Results Compared with baseline, quality of life improved significantly after PCI in terms of both physical component summary and mental component summary [ （51.07 ± 20. 39）scores vs. （61.69 ±19. 73 ） scores and （63.27 ± 20. O0 ） scores vs. （ 68.81 ± 18. 71 ） scores, respectively ; all P〈O. 01]. Multiple linear regression analysis showed that female, diabetes and ST-segment elevation myocardial infarction were independent predictors of physical component summary improvements post PCI （ 13 values were - 0. 310, - 3. 880 and 1. 302, respectively ; P 〈 0. 05 or P 〈 O. 01 ）. Previous PCI and diabetes were independent predictors of mental component summary improvements post PCI （ 13 values were - 1. 483 and - 2. 790, respectively; all P 〈 0. O1 ）. Conclusions Quality of life of acute coronary syndrome patients is significantly improved at 6 months after drug-eluting stents implantation. The predictors of physical quality of life improvement are female, diabetes, and ST-segment elevation myocardial infarction. Predictors of mental quality of life improvement are previous PC1 and diabetes.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2012年第4期293-297,共5页
Chinese Journal of Cardiology
