期刊文献+

使用亚甲蓝检测早期宫颈癌前哨淋巴结的研究 被引量:5

暂未订购
导出
摘要 目的:探讨使用价廉的亚甲蓝注射液检测早期宫颈癌前哨淋巴结(SLN)的可行性并进一步优化操作方法。方法:FIGO分期为Ib1-IIa期的拟行广泛子宫切除+盆腔淋巴结清扫术的宫颈癌患者入选,开腹前10~360min,2~4mL1%亚甲蓝注入77例患者的宫颈肿瘤周围(另4例注入4mL专利蓝),切除后见到的蓝染淋巴结被认为是前哨淋巴结。结果:亚甲蓝的注射剂量达4mL时,SLN的检出率可达93.9%(46/49)。当注射时间距手术开始>60min以上时,SLN的双侧检出率较注射时间<30min的患者明显升高(78.1%vs.47.1%P<0.05)。4例使用专利蓝的患者,其中3例检出单侧SLN且均出现褪色现象,而亚甲蓝蓝染的淋巴结无论是在体内还是在体外均无褪色迹象。检出SLN的112侧盆腔淋巴结中,SLN最常定位在闭孔窝(65.2%,73/112),其次是髂外血管区(30.4%,34/112),髂内动脉(26.8%,30/112)。3例假阴性患者均有明显肿大淋巴结。结论:亚甲蓝对早期宫颈癌而言是一种价廉物美的示踪剂,其理想的注射剂量和注射时间分别为4mL和术前60~90min。
出处 《实用医学杂志》 CAS 北大核心 2012年第8期1322-1325,共4页 The Journal of Practical Medicine
  • 相关文献

参考文献24

  • 1Medl M,Peters-Engl C,Schutz P. First report of lymphatic mapping with isosulfan blue dye and sentinel node biopsy in cervical cancer[J].Anticancer Research,2000,(2B):1133-1134.
  • 2Dargent D,Martin X,Mathevet P. Laparoscopic assessment of the sentinel lymph node in early stage cervical cancer[J].Gynecologic Oncology,2000,(03):411-415.
  • 3O' Boyle J D,Coleman R L,Bernstein S G. Intraoperative lymphatic mapping in cervix cancer patients undergoing radical hysterectomy:a pilot study[J].Gynecologic Oncology,2000,(02):238-243.
  • 4Dargent D,Enria R. Laparoscopic assessment of the sentinel lymph nodes in early cervical cancer.Technique-preliminary results and future developments[J].Critical Reviews in Oncology/Hematology,2003,(03):305-310.
  • 5Kampralh S,Possover M,Schncider A. Laparoscopic sentinel node detection in patients with cervical cancer[J].American Journal of Obstetrics and Gynecology,2000,(06):1648.
  • 6Lantzsch T,Wolters M,Grimm J. Sentinel node procedure in Ib cervical cancer;a preliminary series[J].British Journal of Cancer,2001,(06):791-794.
  • 7Martinez-Palones J M,Gil-Moreno A,Perez-Benavente M A. Intraoperative sentinel node identification in early stage cervical cancer using a combination of radiolabeled albumin injection and isosulfan blue dye injection[J].Gynecologic Oncology,2004,(03):845-850.
  • 8Angiolia R,Palaiaa I,Cipriani C. Role of sentinel lymph node biopsy procedure in cervical cancer;a critical point of view[J].Gynecologic Oncology,2005,(02):504-509.
  • 9Malur S,Krause N,Kohler C. Sentinel lymph node detection in patients with cervical cancer[J].Gynecologic Oncology,2001,(02):254-257.
  • 10Verheijen R H,Pijpers R,van Diest P J. Sentinel node detection in cervical cancer[J].Obstetrics and Gynecology,2000,(01):135-138.

二级参考文献13

  • 1Hatch KD.Cervical cancer,1994.
  • 2Cabanas RM.An approach for the treatment of penile carcinoma[J],1977.
  • 3Delgado G;Bundy BN;Fowler WC Jr.A prospective surgical pathological study of stage I squamous carcinoma of the cervix:a Gynecologic Oncology Group Study[J],1989.
  • 4Magrina JF;Goodrich MA;Lidner TK.Modified radical hysterectomy in the treatment of early squamous cervical cancer[J],1999.
  • 5Noguchi H;Shiozawa I;Sakai Y.Pelvic lymph node metastasis of uterine cervical cancer[J],1987.
  • 6Arens A;Osinga J;Schwipper V.Sentinel lymph node dissection in patients with malignant melanoma: diagnostic and therapeutic standards,2003.
  • 7SinghRanger G;Mokbel K.The evolving role of sentinel lymph node biopsy for breast cancer[J],2003.
  • 8Lantzsch T;Wolters M;Grimm J.Sentinel node procedure in Ib cervical cancer: a preliminary series[J],2001(6).
  • 9Malur S;Krause N;Kohler C.Sentinel lymph node detection in patients with cervical cancer[J],2001.
  • 10张保宁,白月奎,陈国际,陈盛祖,刘琳,杨红鹰,孙耘田.乳腺癌前哨淋巴结活检的临床意义(附30例报告)[J].中华肿瘤杂志,2000,22(5):395-397. 被引量:112

共引文献58

同被引文献34

  • 1吕欣炜,刘开江.腹腔镜下宫颈癌前哨淋巴结检测技术研究进展[J].妇产与遗传(电子版),2012,2(1):43-47. 被引量:1
  • 2Atula T, Hunter KD, Cooper LA, et al. Micrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squa- mous cell carcinoma [ J ]. Eur J Surg Oncol, 2009,35 ( 5 ) : 532 -538.
  • 3李大鹏,盛修贵,李庆水,等.前哨淋巴结活检诊断早期子宫颈癌腹膜后淋巴结转移的临床价值[G]//中国抗癌协会,中华医学会肿瘤学分会.第五届中国肿瘤学术大会论文集,石家庄:河北医科大学第四医院,2008.
  • 4Bats AS, Bu6nerd A, Querleu D, et al. Diagnostic value of intraopera- five examination of sentinel lymph node in early cervical cancer: a prospective, muhicenter study [ J ]. Gynecol Oncol, 2011,123 ( 2 ) : 230 - 235.
  • 5Leong SP.Role of selective sentinel lymph node dissection in head and neck melanoma[J].J Surg Oncol,2011,104(4):361-368.
  • 6John P,Mary L,Neeta P,et al.Sentinel lymph node biopsy in the management of early-stage cervical carcinoma[J].Gynecol Oncol,2011,120(3):347-352.
  • 7Roy M,Bouchard-Fortier G,Popa I,et al.Value of sentinel node mapping in cancer of the cervix[J].Gynecol Oncol,2011,122(2):269-274.
  • 8陈贵廷;薛赛琴.最新国内外疾病诊断标准[M]{H}北京:学苑出版社,1992994.
  • 9Terluk MR,ds Silva-Santos JE,Assreuy J. Involvement of soluble guanylate cyclase and calcium-activated potassium channels in the long-lasting hyporesponsiveness to phenylephrine induced by nitric oxide in rat aorta[J].Naunyn Schmiedbergs Arch Pharmacol,2000,(5):477-483.
  • 10Evgenov OV,Sveinbj(o)rnsson B,Bjertnaes LJ. Continuously infused methylene blue modulates the early cardiopulmonary response to endotoxin in awake sheep[J].{H}ACTA ANAESTHESIOLOGICA SCANDINAVICA,2001,(10):1246-1254.

引证文献5

二级引证文献30

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部