摘要
目的比较肝动脉介入栓塞化疗(TACE)联合伽玛刀治疗与TACE联合三维适形放射治疗原发性肝癌(HCC)的疗效。方法将50例不能手术的Ⅱa或Ⅱb期HCC患者根据患者意愿和适应证分为TACE+伽玛刀治疗组(A组)25例与TACE+三维适形放射治疗组(B组)25例,两组一般情况无统计学差异。A组先行TACE(40%碘化油+CPDD+5-FU+EADM)治疗2～3次后,再进行体部伽玛刀放射治疗。B组先行2～3次TACE治疗后,再行加速器适形放射治疗。结果治疗后3个月评价疗效,A组RR率(CR+PR)为84%(21/25),1、2、3年生存率分别为76%,45.9%,20.44%。B组的RR率为56%(14/25),与A组比较差异有统计学意义(P<0.05),B组1、2、3年生存率分别为79.6%,30.2%,12.6%,与A组比较差异无统计学意义(P>0.05)。结论与TACE联合适形放射治疗相比,TACE联合伽玛刀治疗HCC具有较高的近期有效率,而两种治疗的1、2、3年生存期差异无统计学意义。
Objective To evaluate the effect and tolerance of patients with hepatocellular carcinoma（HCC） treated by γ-ray three-dimensional conformal radiotherapy（3-DCRT） combined with interventional therapy or χ-ray Three Dimensional Conformal Radiation Therapy combined with interventional therapy.Methods From June 2005 to June 2008,50 patients with HCC were randomly divided into γ-ray three-dimensional conformal radiotherapy（3-DCRT） combined with interventional therapy group（n=25） and χ-ray three-dimensional conformal radiotherapy（3-DCRT） combined with interventional therapy group（n=25）.All the 50 cases were firstly treated with TACE.γ-ray 3-DCRT was performed after 2-3 times of TACE in 25 cases and the remaining 25 cases were treated χ-ray 3-DCRT after 2-3 times of TACE.Results The overall response rate of HCC was 84% in TACE combined with γ-ray 3-DCRT group,significantly higher than that in χ-ray 3-DCRT group（56%）（P0.05）.The total effective rate after three months and overall survival rates after 1,2,3 year in TACE combined with γ-ray 3-DCRT group（76% and 45.9%,20.4%,respectively）,while the other group（79.6%and30.2%,12.6%,respectively）,P0.05.Conclusion The overall response rate of HCC in γ-ray 3-DCRT ＋ TACE is better than χ-ray 3-DCRT ＋ TACE for HCC,but the overall survival rates is not significant.
出处
《临床肝胆病杂志》
CAS
2012年第4期264-266,共3页
Journal of Clinical Hepatology
关键词
肝肿瘤
放射疗法
适形
肝动脉介入栓塞化疗
Γ射线
χ射线
liver neoplasms
radiotherapy
nonformal
transcatheter arterial chemoembolization
gamma rays
χ-rays
