摘要
目的 :探讨环磷酰胺 (CTX)对早期小鼠S180 最佳治疗方案 ,为“治愈性”化疗提供科学依据。方法 :六组S180 荷瘤小鼠中 ,五组用CTX腹腔内注射治疗 ,一组用生理盐水对照。治疗后 80天处死全部小鼠并经病理证明无瘤 ,评价为治愈。结果 :在每天CTX 2 0mg/kg和 10 0mg/kg 1次组中 ,治愈率分别为 90 %和 5 0 % (P >0 .0 5 ) ;肿瘤生长死亡率分别为 10 %和 2 0 % (P>0 .0 5 ) ;毒性死亡率分别为 0 %和 30 % (P >0 .0 5 )。在每天 1次CTX 40mg/kg腹腔内注射 ,连续 5次、2 0 0mg/kg 1次和 10 0mg/kg2次组中 ,治愈率分别为 5 0 %、45 %和 30 % ;三组全部无瘤生长 ,毒性死亡率分别为 5 0 %、5 5 %和 70 %。结论 :CTX对早期小鼠S180 有治愈作用 ,CTX每天 2 0mg/kg ,连续 5次治疗是最佳治愈性化疗方案。
?Objective:To evaluate the curative effect and optimal regimen of cyclophosphamide(CTX) in treatment of early stage mice sarcoma 180(S 180 ).Methods:5 of the 6 groups of mices loading with S 180 cells were treated with CTX and 1 group treated with saline as control.All mices were killed 80 days after treatment and examined for pathological changes.Results:Cure rates in CTX ip 20 mg/kg daily for 5 days group and 100 mg/kg single dose group were 90% and 50% respectively( P >0.05),tumor develop rates were 10% and 20% respectively( P >0.05) and toxici mortality was 0% and 30% respectively( P >0.05).In CTX ip 40 mg/kg daily for 5 days,200 mg/kg single dose and 100 mg/kg daily for 2 days groups,the cure rates were 50%,45% and 30% respectively,no tumor grow in all these 3 groups,the toxici mortality was 50%,55% and 70% respectively.Conclusions:CTX have curative effect for mice S 180 in early stage and CTX ip 20 mg/kg daily for 5 days is proved to be the optimal curative chemotherapeutic regimen.
出处
《蚌埠医学院学报》
CAS
2000年第1期3-4,共2页
Journal of Bengbu Medical College
基金
安徽省卫生厅政策性课题〔皖卫科(1994)181 2 2〕
关键词
环磷酰胺
肿瘤
实验性
治愈性化疗
cyclophosphamide
neoplasms,experimental
curative chemotherapy
