摘要
2型糖尿病（T2DM）胰岛素抵抗与胰岛B细胞功能异常的机制包括氧化应激、内质网应激、胰岛淀粉样变性、肌肉与肝脏及胰腺部位异位脂肪沉积、脂毒性以及糖毒性等。上述机制均可因营养过剩而激活，且均可视为某种炎症反应，或与炎症相关。本文就免疫系统参与T2DM致病的有关机制研究以及T2DM抗炎治疗的临床试验做一简要回顾。
Objective To observe the effects of gastric bypass（GBP） on type 2 diabetes mellitus（T2DM） patients with overweight,obese and non-obese.The changes of glucose tolerance on T2DM patients with overweight/obesity and normal weight after GBP surgery were investigated during the follow-up.Methods From January 2006 to June 2007,103 T2DM patients undergoing GBP were recruited and divided into overweight/obese group（BMI≥25 kg/m2）and normal weight group（BMI25 kg/m2）.Patients received oral glucose tolerance test,insulin and C-peptide release test.Both BMI and HbA1c were measured at pre-GBP and at six months,one,two,and three years after GBP.Results During the three years follow-up,among all the patients,total remission rate of T2DM was 87%,91% in overweight/obesity group and 77% in normal weight group.BMI reduced significantly in overweight/obese group with 62 patients（95%） BMI24 kg/m2,while no change of BMI in normal weight group.Compared to the level of insulin secretion in normal weight group at pre-GBP,△I30/△G30 increased significantly at three years post-GBP.HOMA-IR in overweight/obesity group decreased obviously at three years post-GBP compared to pre-GBP.Conclusions GBP could achieve remission of T2DM both in overweight/obese and normal weight patients.However,normal weight patients had a lower rate of glucose normalization than overweight/obese patients,indicating that the effect of GBP on diabetes was independent of weight loss in normal weight patients,while in overweight/obesity patients it was mainly associated with the amelioration of insulin resistance.
出处
《中华糖尿病杂志》
CAS
2012年第4期248-251,共4页
CHINESE JOURNAL OF DIABETES MELLITUS
