摘要
目的：观察脑康复冲剂对血瘀证动物模型体内血栓、体外血栓的作用及对血液流变性的影响，探讨脑康复冲剂预防脑血栓形成药效学机理。方法：兔、大鼠预防性给药，观察脑康复冲剂对兔实验性体外血栓及血液流变性的影响；对大鼠体内血栓的影响。结果：用高分子右旋糖苷造成血瘀证动物模型，表现为血液粘度升高，红细胞聚集性增强等，脑康复冲剂具有抑制体外血栓形成、延长体内血栓形成时间的作用，并能降低动物的血液粘度、抑制血小板的聚集性。结论：脑康复冲剂具有活血化瘀、拮抗血栓形成的功效，其作用机理与降低血小板聚集，改善血液流动状况，防治动物微循环障碍有关。
Objective:To observe the pharmacological action of Naokangfu granule(NKFG) for preventing the cerebral thrombosim.Methods:We used the blood stasis symptom complex modelsind uced by a single injection of 15% high polymar dextran.Observed the preventive and theraputic effects of NKFG in experimantal animals.The effects of the time of the rats neck arterical by thrombosis the rabbits invitro test thrombosis and hemorrheology were examined.Electric current stimulate method by Channels way.Result:NKFG could prolong the time of the rats neck artial thrombosis ,reduce the rabbits thrombus weigth and dry in vitro test ,under lower the amounts of blood viscosity in shear rate ,and decrease platelet adhesion rate and aggregation rate.Conclusion:NKFG could prevent the cerebral thrombosis.The mechanism might improve the hemorrheologic changes caused,reduce the platelet collection.
出处
《河北医学》
CAS
2000年第1期7-10,共4页
Hebei Medicine
关键词
脑康复冲剂
血栓形成
动物模型
中医药疗法
Naokangfu granule
Thrombosis
Platclct collection
Blood stasis symptom comples
Animal models
