摘要
视网膜血管病变中新生血管的发生占有重要地位,是很多视网膜疾病的严重并发症,其发病机制尚未完全明了,综述了胚胎视网膜血管发生方式及其促进因素。人胚胎视网膜血管发生存在两个阶段,第一阶段为视网膜内层血管的发育,由梭形细胞增殖分化形成血管内皮细胞,再改建成血管,第二阶段是外层血管的发育,由已存在的内层血管以出芽方式形成。血管的生成受到多种因素的调节,促进血管新生的调节因子有很多,其中血管内皮生长因子,碱性成纤维细胞生长因子是到目前为止发现最强的促进血管新生的生长因子。
Angiogenesis plays an important role in vascular diseases of the retina and it is a severe complication of many retinal diseases.Until recently,little was known about its pathogenesis.This article reviews the processes and factors that regulate fetal retinal vascular development.The retinal vascularization of human fetus comprises two processes:initially the inner sides of retinal vessels are developed from spindle cells,which then are developed into vascular plexus by differentiation,proliferation and remodelling;the outer sides of retinal vessel arise as cellular buds to form capillary networks.Many factors can modulate angiogenesis,while vascular endothelial growth factor and basic fibroblast growth factor are the stronger factors to promote the angiogenesis.
出处
《眼科研究》
CSCD
2000年第1期89-91,共3页
Chinese Ophthalmic Research
