摘要
许多研究表明非酶糖化和葡萄糖自身氧化伴随着游离基的产生,是一个糖化氧化过程。多原醇途径使视网膜内还原型烟酰胺腺嘌呤二核苷酸(NADH)和氧化型烟酰胺腺嘌呤二核苷酸(NAD+)比率升高,模拟低氧反应,改变了视网膜内氧化还原平衡。非酶糖化和山梨醇途径引起的氧化还原损伤是糖尿病视网膜病变(DR)发生的主要原因之一。
Many studies show that nonenzymatic glycation and glucose autoxidation which are accompanied by generation of free radicals is a process of glycation and oxidation.The polyol pathway increases the retinal ratio of the reduced form of nicotinamide adenine dinucleotide(NADH) and the oxidized form of nicotinamide adenine dinucleotide(NAD +) causing retinal hypoxia like redox imbalance,or “pseudohypoxia”.Oxidative injury caused by nonenzymatic glycation and the polyol pathway is one of major reasons for the occurrence of diabetic retinopathy(DR).
出处
《眼科研究》
CSCD
2000年第1期86-88,共3页
Chinese Ophthalmic Research
关键词
非酶糖化
糖尿病
视网膜病变
糖化氧化
nonenzymatic glycation polyol pathway diabetic retinopathy
