摘要
目的探讨血浆置换用于妊娠期急性脂肪肝(AFLP)的临床疗效及安全性。方法对15例AFLP患者进行血浆置换治疗,并在治疗前后检测肝肾功能、凝血功能及血氨,同时观察不良反应的发生情况。结果经血浆置换治疗后,本组患者临床症状明显改善,浮肿消退,食欲增加,精神好转,且肌酐(Cr)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、白细胞计数(WBC)、血氨水平均低于血浆置换前,血清白蛋白(ALB)、纤维蛋白原(Fg)水平高于血浆置换前,差异均有统计学意义(P<0.05和P<0.01)。但血浆置换前、后尿素氮(BUN)、血小板计数(PLT)水平无明显变化,差异无统计学意义(P>0.05)。术中出现皮肤瘙痒皮疹1例,治疗后出现PLT下降5例,大出血1例。结论血浆置换用于AFLP疗效明确,是有效、安全的。
Objective To conclude the effect and adverse events of plasma exchange（PE） on acute fatty liver of pregnancy（AFLP）.Methods 15 patients with AFLP were treated with PE.Liver,renal and coagulating functions were monitored before and after treatment.Adverse events were recorded at the same time.Results After PE,clinical presentations were improved significantly.Edema was disappeared,psychosis and appetite became better.Creatinine（Cr）,aspartate aminotransferase（AST）,alanine aminotransferase（ALT）,total bilirubin（TBIL）,prothrombin time（PT）,activated partial thromboplastin time（APTT）,white blood cell count（WBC） and blood ammonia average were dcreased,serum albumin（ALB）,fiber fibrinogen（Fg） level were increased,the differences were statistically significant（P0.05 and P0.01）.However,plasma exchange,blood urea nitrogen（BUN）,platelet count（PLT）showed no significant difference（P0.05）.Conclusion PE can be used effectively and safely in treating AFLP.
出处
《临床合理用药杂志》
2012年第11期47-48,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
妊娠期急性脂肪肝
血浆置换
疗效
不良反应
Acute fatty liver of pregnancy
Plasma exchange
Effect
Adverse event
