摘要
目的探讨替吉奥联合顺铂治疗晚期胃癌近期疗效及安全性。方法将130例晚期胃癌患者随机分为观察组和对照组各65例,对照组给予5-氟尿嘧啶联合顺铂治疗,观察组给予替吉奥联合顺铂治疗,观察两组近期疗效及毒副反应情况,并进行对比分析。结果观察组有效率及临床收益率均明显高于对照组,组间比较有显著差异(P<0.05);观察组血红蛋白减少、腹泻及脱发Ⅲ~Ⅳ发生率均低于对照组,组间比较有显著差异(P<0.05)。结论替吉奥联合顺铂治疗晚期胃癌近期疗效好、毒副反应少,是目前临床治疗晚期胃癌的一种较佳治疗方案,值得临床推广应用。
Objective To investigate the efficacy and safety of Gimeracil and Oteracil Potassium Capsules combined with cisplatin to advanced gastric cancer.Method 130 cases with advanced gastric cancer patients were randomly divided into the observation group and the control group,with 65 cases in each group,the control group received 5-fluorouracil and cisplatin treatment,observation group was given in combination with cisplatin for the treatment of Gimeracil and Oteracil Potassium Capsules.Efficacy and toxicity of response were observed and comparatively analyzed.Results The efficiency and clinical benefit rate of the observation group were both significantly higher than those of the control groups,which were significantly different(P 0.05);Hemoglobin reduction,diarrhea and trichomadesisⅢ~Ⅳincidence rate of the observation group was lower than that of the control group,which had significant difference(P 0.05).Conclusion Gimeracil and Oteracil Potassium Capsules combined with cisplatin has better short-term efficacy and less toxicity,which is a better clinical treatment to advanced gastric cancer and worthy of clinical application.
作者
肖晓红
罗娇利
Xiao Xiaohong;Luo Jiaoli(Huarong county Hospital of Traditional Chinese Medicine,Huarong,Hunan,414200;ChangshaCityghHospital,Changsha,Hunan,410001)
出处
《肿瘤药学》
CAS
2011年第6期524-526,共3页
Anti-Tumor Pharmacy
关键词
替吉奥
5-氟尿嘧啶
顺铂
Gimeracil and Oteracil
Potassium Capsules
5-fluorouracil
Cisplatin
Toxicity
