摘要
目的探讨血浆瘦素、血清同型半胱氨酸(Hcy)及胱抑素C(CysC)水平在肾病综合征(NS)患者中的变化及临床意义。方法选择52例肾病综合征患者(研究组)和20例健康体检者(对照组)纳入本研究,分别采用放射免疫测定法(RIA)、化学发光法及ELISA法检测血浆瘦素水平、血清Hcy及CysC水平,并进行比较。结果研究组瘦素、Hcy及CysC水平均显著高于正常对照组,差异均有统计学意义(t=2.97,P<0.05;t=5.35,P<0.01;t=2.60,P<0.05)。结论肾病综合征患者血浆血浆瘦素、血清Hcy及CysC水平显著升高,有助于临床了解肾病综合征患者的病情,观察治疗效果及评估预后。
Objective To investigate the changes and clinical significance of plasma leptin,serum homocysteine（Hcy） and cystatin C（CysC） in patients with nephrotic syndrome（NS）.Methods Fifty two patients with NS（study group） and 20 case of healthy medical examination people（normal control group） were enrolled in our study,radioimmunoassay（RIA）,chemiluminescence and ELISA were respectively applied to determine plasma leptin,serum Hcy and CysC,and results were compared between the two groups.Results The levels of leptin,Hcy and CysC in study group were statistically higher than those of normal control group（t = 2.97,P 0.05;t = 5.35,P 0.01;t = 2.60,P 0.05）.Conclusion Plasma leptin,serum Hcy and CysC are significantly increased in patients with NS,it is beneficial to further understand the conditions,therapeutic effect and prognosis of patients.
出处
《中国当代医药》
2012年第12期70-70,72,共2页
China Modern Medicine
