摘要
目的 :研究凋亡相关蛋白 bcl- 2在口腔正常粘膜、上皮异常增生和鳞癌组织中表达及意义。方法 :采用免疫组化方法检测 10例正常粘膜、10例单纯性增生上皮、30例异常增生上皮、33例鳞癌石蜡包埋样本中 bcl- 2的表达。结果 :bcl- 2在正常粘膜、单纯增生和异常增生白斑表达情况基本一致 ,显弱阳性表达且局限于基底层细胞 ,鳞癌组织中 bcl- 2表达明显高于正常组和白斑组 (P<0 .0 5 )。结论 :bcl- 2基因可能主要在口腔癌发生的后期发挥作用 ,在肿瘤细胞异常增殖的同时 ,进一步抑制细胞的凋亡导致肿瘤的最终发生。 bcl- 2多在鳞癌时出现较强表达 ,为临床监测异常增生的转归可能具有一定的指导意义。
Objective:To study the expression and signficance of a poptosis related protein bcl 2 in Oral normal mucosa,leukoplakia(LK) and squamoous cell carcinoma(SCC).Methods:The expression was observed in 10 normal epithelial,10 simple hyperplasia LK,30 epithelial dysplasic LK and 33 SCC by Immunohistochemical evaluation.Results:In normal mucosa and LK,the positive bcl 2 exepression was similar(P>0.05),and was comfined to basialis cell.There was a significant elevation of bcl 2 exepression in SCC(P<0.05).Further analysis showed that the correlation was evident between expression of these two proteins in SCC but not in LK.Conclusion:The abnormal bcl 2 expression resulted in the progression of SCC.The bcl 2 marker had a clinical significance in monitoring the dysplasis LK transform.
出处
《肿瘤研究与临床》
CAS
2000年第2期98-99,共2页
Cancer Research and Clinic
基金
福建省教委基金
