摘要
目的 :观察 39例 PHC病人经化疗栓塞后联合应用经冷冻肝癌瘤苗刺激的肿瘤浸润淋巴细胞 (s-TIL )前后外周血 T淋巴细胞亚群的变化。方法 :于化疗栓塞及应用 s- TIL前、治疗后 7d、14d、2 1d分别查 T淋巴细胞亚群 ,并与对照组比较。结果 :肝癌病人经化疗栓塞后 CD+ 3、CD+ 4 、CD+ 8、CD+ 4 / CD+ 8比值约在 14d左右即上升 ,与对照组比较有显著性差异 (P<0 .0 5 )。结论 :TACE后联合应用 s- TIL细胞具有提高机体细胞免疫功能的作用。
Objective:To observe the changes of peripheral blood lymphocyte subsets in patients with PHC treated by tumor infiltrating lymphocytes(TIL) stimulated by liver tumor cryovaccines after transcather arterial chemoembolization(TACE).Methods:Peripheral blood T lymphocyte subsets were detected before treated by TACE and s TIL in the 7,14,21 days after treatment respectively, and compared with controls.Results:The values of CD + 3, CD + 4,CD + 8,CD + 4/CD + 8 in patients with PHC rose about 14 days treated by TACE and s TIL, and were significant compared with controls(P<0.05).Conclusion:This study suggests that the application of s TIL after using TACE can obviously enhance the cellular immunity, and it provides a new treatment for PHC.
出处
《肿瘤研究与临床》
CAS
2000年第2期86-88,共3页
Cancer Research and Clinic
基金
广西壮族自治区科技厅资助课题!( 95 3 2 0 2 9)
