摘要
目的 :探讨肿瘤血管生长因子 (TAF)在原发性肝癌血清中的表达及其意义。方法 :对 184例临床确诊的原发性肝癌 (肝癌 )病人行 FAM方案肝动脉化疗栓塞术。应用生化比色定量法分别检测术前、术后血清 TAF的表达水平 ,并且与血清中甲胎蛋白 (AFP)表达、肿瘤大小、碘化油栓塞剂肿物充填量及其形态分布进行比较分析。结果 :全部病例 TAF术前、术后水平均高于正常水平 (P<0 .0 5 )。肝癌病人中仍有 30 .4% (5 6 / 184) AFP<2 0μg/ L,其术前、术后 TAF水平与 AFP阳性病例无显著性差异 (P>0 .0 5 ) ;TAF在介入术前后的下降程度与肿瘤的缩小幅度。碘化油充填肿瘤的大小及分布情况均有一定的相关性。结论 :血清 TAF表达结合 AFP检测及影像学检查可以早期发现原发性肝癌 ,减少漏诊率。并对肝癌的肿瘤瘤体情况、治疗疗效以及预后动态观察具有实用价值。
Objective:To evaluate the significance of tumor angiogenesis factor (TAF) expression in primary hepatic carcinoma.Methods:Transcatheter arterial chemotherapy embolization (TACE) was applied to 184 patients with primary carcinoma(PHC).The expression of TAF was determined by col method meters,and the relations among TAF, A Fetoprotein(AFP),Lipiodoldeposition was studied.Results:The serum TAF level dropped markedly after TACE of patients with PHC (P<0.05).The serum TAF concentration was significantly higher in patients of PHC with AFP negative reaction than those after TACE (P<0.05),TAF is a remarkable and effective index,and the change of TAF is accordant with the size reduction of tumor and the Lipiodoldeposition.Conclusion:Expression of TAF can be used as an early biomarker identifying premalignant lesions.Detection of serum TAF is of significance in the prognosis of PHC.
出处
《肿瘤研究与临床》
CAS
2000年第2期81-83,共3页
Cancer Research and Clinic
关键词
原发性肝癌
肿瘤标志物
TAF
Tumor Angiogenesis Factor(TAF)
Primary Hepatic Carcinoma(PHC)
Tumor Marker
