摘要
目的 研究p16蛋白在前列腺癌及非典型增生中的表达。方法 采用免疫组织化学 (ABC)法 ,对 40例前列腺癌及 3 0例前列腺非典型增生进行p16蛋白的免疫组化检测。结果 40例前列腺癌中有 18例为阳性反应 ( 4 5 % ) ,3 0例前列腺非典型增生中 7例为阳性反应 ( 2 3 % ) ,p16蛋白在前列腺癌中的表达明显高于前列腺非典型增生。结论 p16基因在前列腺癌的发生发展中发挥重要作用。
Objective To investigate the expression of p16 protein in prostatic carcinoma and dysplasia.Method Immunohistochemistry (ABC) assay was used to carry out immunohistochmical detection of p16 protein in 40 cases of prostatic carcinoma and 30 cases of protatic dysplasia.Results in 40 cases of prostatic carcinoma 18 cases showed positive staining of p16 protein (45%) in 30 cases of prostatic dysplasia 7 cases showed positive staining of p16protein (23%).The expression level of p16 protein in prostatic cacinoma was markedly heigher than that of dysplasia.Conclusion The results show that p16 gene plays an important role in carcinogenesis and development of prostate.
出处
《河南肿瘤学杂志》
2000年第2期83-84,共2页
Henan Journal of Oncology
