摘要
目的探讨脂肪变性供肝（SLD）在背驮式肝移植中的应用。方法将64例SLD进行了背驮式肝移植，其中脂肪变性程度分级为轻（S，级）、中（S2级）、重（S3级）者分别为22、25和17例，随机抽出同期80例供肝无脂肪变性者作为对照。观察手术当天受者的肝、肾功能，术后近期肝功能恢复情况，术后1个月的并发症发生情况，以及受者的死亡情况。结果与对照组比较，手术当天各级脂肪变性组的肝、肾功能的差异均无统计学意义（P〉O．05）。术后21d，对照组95％受者的肝功能恢复正常，S1级组、S级组和S3级组分别为90．9%、80．0％和70．6％，S3级组有2例（11．8％）发生移植物原发性无功能。S1、S2和S3；组分别与对照组比较，出血、感染、肝动脉栓塞、腹水、败血症等并发症发生率的差异有统计学意义（P〈0．05）。术后1年内，对照组死亡2例，S1级组死亡1例，S2级组死亡1例，S3级组死亡5例。结论SLD可以用于移植，但对重度脂肪变性肝脏的移植，即使在目前供者紧张的情况下，也应审慎进行。
Objective To explore the application of steatosis liver donor （SLD） in piggyback liver transplantation （PBLT）. Methods Sixty-four cases of SLD were subjected to PBLT and classified into light steatosis liver （S1, 22 cases）, moderate steatosis liver （S2, 25 cases）, and severe steatosis liver （83, 17 cases） groups. Eighty cases of non-fatty liver selected randomly in the same period served as controls. The liver and renal function at the day of surgery, postoperative liver function recovery, complications one month after surgery, and the death of recipients were recorded. Results There was no significant difference in the liver and renal function between steatosis liver groups and control group at the day of surgery （P〉0. 05）. At 21st day after surgery, l%, liver function of 95% recipients in control group returned to the normal level, and the liver function recovery rate in S1, S2 and S3 groups was 90. 9%, 80. 0%, and 70. 6% respectively. Graft primary nonfunction occurred in 2 cases （11.8%） of S3 group. The incidence of complications such as bleeding, infection, hepatic artery thrombosis, ascites, sepsis in S1,S2 and S3 groups was higher than in control group （P〈0. 05）. One year after operation, there were two deaths in control group, one in S1 group, one in S2 group, and 5 in S3 group, respectively. Conclusion SLD can be used for transplantation, but for the transplantation with severe steatosis liver, it should be carried out carefully.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2012年第4期205-207,共3页
Chinese Journal of Organ Transplantation
基金
中央高校基本科研业务费专项资金（303273442
303275899
303274777
303274073
303275111）
武汉市科技攻关项目（303121385）
关键词
肝移植
组织供者
脂肪肝
Liver transplantatiomTissue donors
Fatty liver
