摘要
目的探讨内皮生长因子(EGF)基因多态性与肝细胞性肝癌(HCC)发病风险的关系。方法计算机系统检索PubMed、EMABSE和中国知网等数据库,收集关于EGF61A/G基因多态性与HCC易感性的病例对照研究,并从纳入文献中提取相关数据进行Meta分析。以病例组和对照组EGF61A/G基因型分布的比值比(OR)为效应指标,对纳入文献进行异质性检验,应用Stata 10.1软件对各研究原始数据进行合并分析,计算合并OR值及其95%可信区间(CI)。结果共有6篇文献符合纳入标准,累计病例1 304例,对照2 613例。G/G基因型与G/A+A/A基因型比较的OR值为1.34(95%CI1.16～1.54,P<0.001;I2=36%)。而A/A基因型与G/G+G/A基因型比较的OR值为0.66(95%CI0.53～0.83,P<0.001;I2=0%)。结论 EGF61G/G基因型为罹患HCC的易感基因型,而EGF61A/A基因型则为HCC的保护基因型。
Objective To explore the relationship between polymorphism of epidermal growth factor（EGF） 61A/G and the risk of hepatocellular carcinoma（HCC）.Methods Electronic searches of PubMed,EMBASE and CNKI were systematically conducted to select studies.Case-control studies containing available genotype frequencies of EGF 61A/G were chose.Odds ratio（OR） with 95% confidence interval（CI） was used to assess the strength of this association.Results Six case-control studies including 1 304 cases and 2 613 controls were performed.Meta-analysis showed significant effect of EGF 61A/G on HCC risk and protection（G/G vs.G/A＋A/A：OR=1.34,95%CI=1.16~1.54;A/A vs.G/G＋G/A：OR=0.66,95% CI=0.53~0.83）.Conclusion The EGF 61G allele is a risk factor of HCC;however,the EGF 61A allele is a protective factor of HCC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2012年第4期460-463,共4页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金资助项目(81160262/H1602)
