摘要
目的:通过实验论证临床配药后混合药液的内毒素是否迭加。方法:对医院常用的3个静脉配液处方配制后的混合液体,均用标示灵敏度为0.25 Eu.mL-1的鲎试剂,进行细菌内毒检查实验。结果:3个处方配伍后的液体,细菌内毒素限量实验均未出现阳性,结果无差异。结论:以大溶量注射剂(大输液)作为药物的溶媒或载体的药物配伍,小溶量注射剂的加入所考虑引起的内毒素迭加的理论,无实验支持数据,可以考虑几乎无迭加。
Objective：If correct that the theory of bacteria endotoxins overlays is expounded and prove by the test.Methods：Medicine of liquid after making up on the hospital general three prescriptions,all with indicate sensitivity is 0.25 Eu·mL-1 of the limulus.Check for bacterial endotoxin test.Results：Three prescriptions medicine of liquid after making up.The ＂＋＂ do not appears masculine gender turned out in the bacteria endotoxins limits the quantity of and test.The inspection turned out to be without the difference.Conclusion：With great capacity as solvent drug compatibility injection.,consider joining a small volume stack injection caused by theory of bacteria endotoxins overlays.Be without the test and support the data,may consider not to overlay the effect.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2012年第4期658-660,共3页
Chinese Journal of Pharmaceutical Analysis
关键词
临床配药
细菌内毒素
鲎试剂
药物配伍
用药安全
drug is making up of clinical
bacteria endotoxins
tachypleus amebocyte lysate
drug compatibility
medication safety
