摘要
成体干细胞的自我更新和分化与其微环境关系密切。精原干细胞(spermatogonial stem cells,SSCs)是体内自然状态下唯一能将遗传信息传至子代的成体干细胞。探讨SSCs更新和分化的调控机制有助于精子发生机理的阐明,并为探究其他成体干细胞增殖分化的调节机制提供依据。因此,SSCs系统为成体干细胞微环境研究提供了理想模型。资料表明,SSCs的更新和分化受其微环境的调控。基于本室的工作,参考最新文献,本文主要从SSCs微环境的基本特性、构成及其产生的各种调控因子等角度,评述了SSCs微环境的生物学特性及其与SSCs更新和分化间的关系,以期为本领域研究及其他成体干细胞相关研究提供借鉴。
The self-renewal and differentiation of adult stem cells are closely related to their niches.Naturally,spermatogonial stem cells（SSCs） are the only adult stem cells in the body,which can transfer genetic information into the offspring.An insight into the modulation of the self-renewal and differentiation of SSCs can help elucidate the mechanisms of spermatogenesis and investigate the proliferation and differentiation of other adult stem cells.Therefore,the SSC system provides an ideal model for researches on the adult stem cell niche.More and more evidence indicates that the self-renewal and differentiation of SSCs are regulated by their niches.Based on our previous work and other related findings recently reported,this article presents an overview on the biological properties of SSC niches and their relationship with the self-renewal and differentiation of SSCs,focusing on the basic properties and components of SSC niches and various regulatory factors they produce.
出处
《中华男科学杂志》
CAS
CSCD
2012年第4期359-363,共5页
National Journal of Andrology
基金
国家自然科学基金(30771555)
吉林大学基本科研业务费资助项目(200903333)~~
关键词
精原干细胞
干细胞微环境
自我更新
分化
spermatogonial stem cell
stem cell niche
self-renewal
differentiation
