摘要
目的:观察复方丹参滴丸对大鼠肝纤维化作用的组织病理学影响。方法:按2 mL·kg-1(10μg·kg-1)剂量ip0.5%二甲基亚硝胺水溶液,每天1次,每周的第1,2,3天注射,连续4周。手术取大鼠肝中叶组织,进行病理组织学活检,确定和筛选成功模型。用复方丹参滴丸以292,146,73 mg·kg-1剂量,ig连续治疗30 d。观察肝脏组织病理形态变化,并用IPP 5.0图像分析软件计算肝纤维化面积。结果:复方丹参滴丸治疗4周后,292,146,73 mg·kg-1剂量组大鼠肝纤维化面积分别减少(1 602±1 966),(631±1 589),(2 759±1 965)μm2,与模型组比较有显著差异(P<0.01)。同组治疗前后比较均减少,但差异不明显。结论:复方丹参滴丸对肝纤维化具有一定的治疗作用。
Objective：To observe the histopathology effect of compound Danshen droppills on hepatic fibrosis in rats.Method： Wistar rats was injected 0.5% dimethylnitrosamine solution for 3 days,lasted for 4 weeks（2 mL·kg-1,once a day） to establish hepatic fibrosis model.The model was determined by biopsy and treated by Danshen droppills（292,146,73 mg·kg-1）through intragastric administration for 30 days.The histopathology of liver was observed and the size of hepatic fibrosis was calculated through IPP 5.0 soft ware.Result： After treatment for 4 weeks,the size of hepatic fibrosis in the 292,146,73 mg·kg-1 group was reduced（1 602±1 966）,（631±1 589）,（2 759±1 965）μm2 respectively,compared with model group,the three groups mentioned above had significant difference（P0.01）.For the same group,there was no significant difference before and after treatment.Conclusion：The result showed that compound Danshen droppills has therapeutic effect on rat hepatic fibrosis.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第8期246-248,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
天津市现代中药重点实验室-省部共建国家重点实验室培育基地
滨海新区科技特派员科技专项(SB20080085)
关键词
肝纤维化
复方丹参滴丸
病理形态
hepatic fibrosis
compound Danshen droppills
histopathology
