摘要
目的探讨紫绀型先天性心脏病（简称紫绀型先心病）患者颅内血管密度增高的CT表现及机制。方法回顾性分析82例紫绀型先心病患者术前头颅CT平扫和临床资料，按颅内血管密度增高程度分为正常密度组、轻度增高组、中度增高组及重度增高组，将血管密度增高程度与血红蛋白（Hb）浓度、红细胞计数（RBC）、红细胞压积（HCT）值及临床紫绀程度进行对比分析。不同组间静脉窦内血液CT值及Hb、RBC、HCT值的比较采用方差分析；对血液CT值与Hb浓度的相关性进行描述性分析和直线回归分析；血管密度与紫绀程度的相关性采用Spearman等级相关分析。结果82例中，CT表现脑血管密度正常12例（14．6％），脑血管密度增高70例（85．4％）。其中，轻度增高组22例（26．8％），CT值为（55．4±2．6）HU，Hb浓度为（169±6）g／L，RBC为（5．8±0．3）×10^12／L，HCT为0．51±0．03；中度增高组29例（35．4％），CT值为（61．3±2．9）HU，Hb浓度为（209±15）g／L，RBC为（7．1±0．4）×10^12／L，HCT为0．66±0．06；重度增高组19例（23．2％），CT值为（68．8±4．2）HU，Hb浓度为（242±23）g／L，RBC为（8．3±0．9）×10^12／L，HCT为0．78±0．08。不同组间血液CT值及Hb、RBC、HCT值差异均有统计学意义（F值分别为163．263、134．703、120．974、136．541，P值均〈0．01）。血液CT值与Hb浓度呈正相关（r=0．98，P〈0．01）。血管密度与紫绀程度呈等级正相关（r=0．86，P〈0．01）。结论紫绀型先心病患者颅内血管密度多呈不同程度增高，增高程度与Hb浓度正相关；临床上与紫绀程度正相关。
Objective To investigate CT features on increased cerebral vascular density and its pathological mechanism in patients with cyanotic congenital heart disease（CCHD）. Methods Preoperative brain CT scan and clinical data in 82 patients suffering from CCHD were analyzed. According to the increased levels of vascular density, patients were divided into 4 groups： normal, mild, moderate and severe. Relationships between the increased levels of vascular density and Hb, RBC, HCT, as well as the degree of cyanosis, were studied. AVONA was carried out to test blood CT value of cerebral sinuses, Hb, RBC and HCT in different groups. Descriptive analysis and linear regression were adopted to study the correlation between blood CT value and Hb concentration. The relationship of increased vascular density to degrees of cyanosis was analysed by Spearman. Results Among 82 patients, 12 patients （ 14. 6% ） were found in the group of normal vascular density and 70 patients （ 85.4% ） in the increased vascular density group. Among 70 patients with increased vascular density, 22 patients （26. 8% ） with （55.4 ±2. 6）HU, （ 169 ±6） g/L of Hb, （5.8 ± 0. 3） ×1012/L of RBC and 0. 51 ±0. 03 of HCT, 29 patients （35.4%） with （61.3±2. 9） HU, （209 ±15） g/L, （7. 1 ±0. 4）×1012/L,0. 66 ±0. 06 and 19 patients （23.2%） with （ 68. 8 ±4. 2 ） HU, （ 242 ±23 ） g/L, （ 8.3 ±0. 9 ）× 1012/L,0. 78 ±0. 08 were observed in the mild, moderate and severe group, respectively. There were significant differences in distribution of blood CT value （ HU）,Hb, RBC and HCT in different groups （ F = 163. 263,134. 703,120. 974,136. 541 ; P 〈 0. 01 ）. Blood CT value was positively correlated with Hb concentration （ r = 0. 98, P 〈 0. 01 ）. Vascular density was also positively correlated with the degree of cyanosis （ r = 0. 86, P 〈 0.01 ）. Conclusions Cerebral vascular density of patients suffering from CCHD presented different levels of increases based on CT scan resuhs due to rise of RBC stimulated by anoxia. The increased level of vascular density was positively correlated with blood Hb concentration, and also associated with RBC accumulation caused by abnormal blood circulation. Moreover, it was positively correlated with the degree of cyanosis.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2012年第4期300-303,共4页
Chinese Journal of Radiology
