摘要
目的:探讨高强度聚焦超声(HIFU)联合过继免疫治疗晚期原发性肝细胞癌(HCC)的临床疗效和应用价值。方法:选择50位诊断明确的晚期HCC患者,随机分为2组。海扶组25例,接受单纯HIFU治疗;综合组25例,除给予HIFU治疗外,还接受自身树突状细胞(DC)和细胞因子诱导的杀伤细胞(CIK)回输治疗。比较2组患者的临床疗效。结果:治疗后综合组患者的生活质量、肿瘤标志物、肝功、免疫状态、生存时间等指标均优于单纯HIFU组(P<0.05)。结论:HIFU与DC-CIK过继免疫具有协同治疗效果,HIFU联合DC-CIK能提高晚期HCC患者的临床疗效。
Objective： To study the clinical effect and value of high intensity focused ultrasound（HIFU） combined with adoptive immunotherapy on patient with advanced hepatocellular carcinoma.Methods： Fifty patients who were suffering from advanced HCC were divided into two groups randomly.25 patients of HIFU group were treated by HIFU only and other 25 patients of joint group were treated by HIFU and adoptive immunotherapy（dendritic cell and cytokine-induced killer cell,DC-CIK）.Results： After treatment,quality of life,AFP,immune functions and survival time in joint group were much better than HIFU group（P 0.05）.Conclusion： HIFU and DC-CIK have synergistic therapeutic effect,HIFU plus CIK can improve curative effect of patients with advanced hepatocellular carcinoma.
出处
《现代肿瘤医学》
CAS
2012年第4期754-757,共4页
Journal of Modern Oncology
基金
四川省卫生厅科学研究项目(编号:080030)
关键词
原发性肝细胞癌
高强度聚焦超声
过继免疫
树突细胞
细胞因子诱导杀伤细胞
hepatocellular carcinoma
high intensity focused ultrasound
adoptive immunotherapy
dendritic cells
cytokine-induced killer cells
