期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

联合检测血清CEA与CYFRA21-1在肺癌诊断中的应用 被引量：2

Application of combined detection of CEA and CYFRA21-1 in the serum from lung cancer patients
暂未订购
导出
摘要 目的:探讨癌胚抗原(CEA)与细胞角蛋白19片段(CYFRA21-1)联合检测在肺癌诊断中的应用价值。方法:采用电化学发光方法检测116例肺癌患者与10例正常人血清中CEA与CYFRA21-1的水平。结果:肺癌患者血清中CEA与CYFRA21-1水平明显高于健康对照组(P<0.05);CEA与CYFRA21-1在肺癌中的检测率分别为41.2%与42.6%,二者联合检测敏感性与准确性均有明显提高;治疗后CEA与CYFRA21-1含量与治疗前相比显著降低(P<0.05)。结论:CEA与CYFRA21-1联合检测可明显提高肺癌诊断阳性率,对临床诊断与疗效评价有一定的应用价值。 Objective：To investigate the diagnostic value of combined detection of CEA and CYFRA21-1 in serum of patients with lung cancer.Methods： Serum levels of CEA and CYFRA21-1 were measured by electrochemiluminescence assay in 10 normal adults and 116 patients with lung cancer.Results： The levels of CEA in patients with lung cancer were obviously higher than those in control group（P0.05）.Sensitivity and veracity of combined detection was significantly increased（P0.05）.Conclusion： Combined detection of CEA and CYFRA21-1 has a notable value in clinical diagnosis and therapeutic evaluation for patients with lung cancer.
作者 庄珊珊 冉永刚 张玉玲 陈炯玉 方裕森
机构地区 汕头大学医学院附属肿瘤医院 白求恩军医学院
出处 《现代肿瘤医学》 CAS 2012年第4期739-740,共2页 Journal of Modern Oncology
关键词 肺癌 CEA CYFRA21-1 联合检测 lung cancer CEA CYFRA21-1 combined detection
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Zheng GX,Wang CX,Qu X. Establishment of serum protein pattern for screening colorectal cancer using SELDI-TOFMS[J].Experimental Oncology,2006,(04):282-287.
  • 2Liska V,Holubec L Jr,Treska V. Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer[J].Anticancer Research,2011,(04):1447-1451.
  • 3Mercatali L,Ibrahim T,Sacanna E. Bone metastases detection by circulating biomarkers:OPG and RANK-L[J].International Journal of Oncology,2011,(01):255-261.
  • 4Brand RE,Nolen BM,Zeh HJ. Serum biomarker panels for the detection of pancreatic Cancer[J].Clinical Cancer Research,2011,(04):805-816.
  • 5Liebhardt S,Ditsch N,Nieuwland R. CEA-,Her2/neu-,BCRP-and Hsp27-positive microparticles in breast cancer patients[J].Anticancer Research,2010,(05):1707-1712.
  • 6Agrawal AK,Jelen M,Rudnicki J. The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type[J].Pathology,2010,(03):224-228.
  • 7Wang J,Yi Y,Li B. CYFRA21-1 can predict the sensitivity to chemoradiotherapy of non-small-cell lung carcinoma[J].Biomarkers:Biochemical Indicators of Exposure,Response Andsusceptibility to Chemicals,2010,(07):594-601.
  • 8Zhu WQ,Yu JM,Sun XD. Serum CYFRA21-1 as a prognoetic marker for patients with undifferentiated nasopharyngeal carcinoma[J].Biomarkers:Biochemical Indicators of Exposure,Response Andsusceptibility to Chemicals,2010,(07):602-607.
  • 9Suzuki H,Hirashima T,Kobayashi M. Cytokeratin 19 fragment/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma[J].Anticancer Research,2010,(10):4343-4346.

同被引文献19

  • 1孙燕,万德森,李进,等.肿瘤学临床实践指南(NCCN)中国版[M].北京:人民卫生出版社,2011:55.
  • 2Gridelli C ,Langer C ,Malone P,et al. Lung cancer in the elderly[ J]. J Clin 0ncol.2007(25) :1898 -1907.
  • 3支修益.原发性肺癌诊疗规范(2011年版)[M].北京:中国学术期刊网络出版社,2011:3.
  • 4耿国军.非小细胞肺癌l临床实践指南(2012版)[EB].ge,J622.haodf.com,2012-10-10.
  • 5Mercatali L, Ibrahim T, Sacanna E, et al. Bone metastases detec- tionby circulating biomarkers:OPG and RANK - L[ J]. Int J On- col,2011,39( 1 ) :255 - 261.
  • 6Kato K, Hitsuda Y, Kawasaki Y, et al. The value of serum Creac- tive protein as a survival determinant in patient s with advanced non- small cell lung cancer[ J]. Nihon Kokyuki Gak kai Zassh i, 2000,38(8) :575 -580.
  • 7Wai PY,Kou PC. Osteopontin:regulation in tumor metastasis[J].{H}CANCER AND METASTASIS REVIEWS,2008,(01):103-118.
  • 8Shevde LA,Das S,Clark DW. Osteopontin:an effector and an effect of tumor metastasis[J].{H}CURRENT MOLECULAR MEDICINE,2010,(01):71-81.
  • 9Celetti A,Testa D,Staibano S. Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness[J].{H}Clinical Cancer Research,2005.8019-8027.
  • 10Patani N,Jouhra F,Jiang W. Osteopontin expression profiles predict pathological and clinical outcome in breast cancer[J].{H}Anticancer Research,2008,(6B):4105-4110.

引证文献2

二级引证文献2

现代肿瘤医学
2012年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部