摘要
目的 探讨腺苷预处理对心脏直视手术的心肌保护效果。 方法 30例择期心瓣膜置换术患者随机分成实验组和对照组 ,每组 15例。实验组在术前行腺苷预处理。分别于转流前、主动脉阻断 30分钟和 6 0分钟、主动脉开放后 30分钟及术后 2 4小时采血测定心肌肌钙蛋白 T(c Tn T)、心肌酶谱和丙二醛。 结果 腺苷预处理者 c Tn T和心肌酶外漏明显减少 ,丙二醛生成减少。 结论 腺苷预处理能减轻心肌缺血再灌注损伤。
Objective\ To investigate the myocardial protective effects of adenosine preconditioning in patients undergoing open heart operation.\ Methods\ Tirty patients with cardiac valve replacement were randomly divided into experimental group and control group with 15 cases in each group. Adenosine preconditioning was elicited in experimental group before the extracorporeal circulation. cTroponin T(cTnT), myocardium enzymes and malondialdehyde were measured in each group respectively before bypass, 30 and 60 minutes after the aorta clamping, 30 minutes after the aorta off clamping, 24 hours after the operation.\ Results\ Adenosine preconditioning alleviated significantly the exudation of cTnT and myocardium enzymes, reduced the malondialdehyde content.\ Conclusion\ Adenosine preconditioning can reduce myocardium ischemic reperfusion injury.
出处
《中国胸心血管外科临床杂志》
2000年第2期86-88,共3页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
腺苷
缺血预处理
心肌肌钙蛋白
体外循环
Adenosine Ischemic preconditioning cTroponin Extracorporeal circulation
